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HomeProduct name listBENZAMIDINE

BENZAMIDINE

  • CAS NO.:618-39-3
  • Empirical Formula: C7H8N2
  • Molecular Weight: 120.15
  • MDL number: MFCD00042826
  • EINECS: 210-546-3
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-05-04 17:34:40
BENZAMIDINE Structural

What is BENZAMIDINE?

The Uses of BENZAMIDINE

Benzamidine was used in the preparation of heparan sulfate-rich proteoglycan from mouse mammary epithelial cells. It has been used to prevent enzymatic degradation during the purification procedure of bovine factor XII (Hageman factor).

What are the applications of Application

Benzamidine is a plasmin inhibitor used in glucagon radioimunoassays

Definition

ChEBI: Benzamidine is a carboxamidine that is benzene carrying an amidino group. It has a role as a serine protease inhibitor. It is a member of benzenes and a carboxamidine. It is functionally related to a benzoic acid. It is a conjugate base of a benzamidine(1+).

Synthesis Reference(s)

The Journal of Organic Chemistry, 27, p. 1255, 1962 DOI: 10.1021/jo01051a033
Tetrahedron Letters, 31, p. 1969, 1990 DOI: 10.1016/S0040-4039(00)88891-7

Biochem/physiol Actions

Benzamidine is an inhibitor of plasmin and has been used in the radioimmunoassay of glucagon in human plasma. It prevents the destruction of Thyrotropin-releasing hormone (TRH) added to whole blood in vitro before radioimmunoassay of TRH.

Purification Methods

It is liberated from its hydrochloride chloride (below) by treatment with 5M NaOH, extracted into diethyl ether, dried (Na2SO4) and sublimed in vacuo.[Beilstein 9 H 280, 9 I 123, 9 II 199, 9 1264, 9 IV 898.]

Properties of BENZAMIDINE

Melting point: 65-70 °C
Boiling point: 208.5±23.0 °C(Predicted)
Density  1.09±0.1 g/cm3(Predicted)
storage temp.  -20°C Freezer
solubility  Chloroform (Slightly), Methanol (Slightly)
form  powder or crystals
pka 11.90±0.40(Predicted)
color  White to Off-White
BRN  606020

Safety information for BENZAMIDINE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H319:Serious eye damage/eye irritation
Precautionary Statement Codes P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for BENZAMIDINE

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