Benzamide, N-(2-(diethylamino)ethyl)-4-((methylsulfonyl)amino)-, monoh ydrochloride
Synonym(s):CK-1752A;N-[2-(Diethylamino)ethyl]-4′-[(methylsulfonyl)amino]benzamide monohydrochloride monohydrate
- CAS NO.：101526-62-9
- Empirical Formula: C14H23N3O3SHClH2O
- Molecular Weight: 0
- MDL number: MFCD11041004
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-18 17:01:59
What is Benzamide, N-(2-(diethylamino)ethyl)-4-((methylsulfonyl)amino)-, monoh ydrochloride?
The Uses of Benzamide, N-(2-(diethylamino)ethyl)-4-((methylsulfonyl)amino)-, monoh ydrochloride
Cardiac depressant (anti-arrhythmic).
The Uses of Benzamide, N-(2-(diethylamino)ethyl)-4-((methylsulfonyl)amino)-, monoh ydrochloride
Sematilide, also known as CK-1752, is a class III antiarrhythmic. It is a selective delayed rectifier K+ current (IKr) channel blocker. It inhibits rapidly activating Ik in guinea pig atrial myocytes, resulting in the prolongation of action potential duration and refractoriness.
Properties of Benzamide, N-(2-(diethylamino)ethyl)-4-((methylsulfonyl)amino)-, monoh ydrochloride
| Melting point: | 141-142° (Lumma); mp 137° and mp 142° (Argentieri) |
| storage temp. | 2-8°C |
| solubility | H2O: ≥16mg/mL |
| form | powder |
| pka | pKa1 7.60; pKa2 9.51(at 25℃) |
| color | white to beige |
Safety information for Benzamide, N-(2-(diethylamino)ethyl)-4-((methylsulfonyl)amino)-, monoh ydrochloride
Computed Descriptors for Benzamide, N-(2-(diethylamino)ethyl)-4-((methylsulfonyl)amino)-, monoh ydrochloride
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