Benperidol

Chemical properties

White or almost white powder.

Originator

Frenactil,Clin-Comar-Byla,France,1965

The Uses of Benperidol

Antipsychotic.

Background

Benperidol has been used in trials studying the treatment of Dementia, Depression, Schizophrenia, Anxiety Disorders, and Psychosomatic Disorders, among others.

Definition

ChEBI: 3-[1-[4-(4-fluorophenyl)-4-oxobutyl]-4-piperidinyl]-1H-benzimidazol-2-one is an aromatic ketone.

Manufacturing Process

A mixture of 3.4 parts of γ-chloro-4-fluorobutyrophenone, 4 parts of 1-(4- piperidyl)-2-benzimidazolinone hydrochloride, 6 parts of sodium carbonate and 0.1 part of potassium iodide in 176 parts of 4-methyl-2-pentanone is stirred and refluxed for 48 hours. The reaction mixture is cooled and 120 parts of water is added. The separated organic layer is dried over magnesium sulfate and the solvent is evaporated to leave an oily residue which is dissolved in dilute hydrochloric acid and boiled. The acidic solution is filtered and cooled at room temperature whereupon there crystallizes from solution 1-(1-[γ-(4- fluorobenzoyl)propyl] -4-piperidyl)-2-benzimidazolinone hydrochloride hydrate melting at about 134°-142°C.

Therapeutic Function

Tranquilizer

Metabolism

Not Available