barbexaclone

Originator

Maliasin,Knoll,Italy,1983

Manufacturing Process

25.4 g of sodium salt of phenyl ethyl barbituric acid and 19.1 g of 1- cyclohexyl-2-methylamino propane hydrochloride are boiled under reflux in a mixture of 125 cc of acetic acid ethyl ester and 125 cc of ethanol. After boiling for half an hour, the solution is filtered, while still hot, to separate the precipitated sodium chloride. The filtrate is concentrated by evaporation to about half its volume. After cooling 42.5 g of the salt of 1-cyclohexyl-2- methylamino propane and of phenyl ethyl barbituric acid are obtained in crystalline form. Its melting point is 130°-133°C.

brand name

Maliasin (Knoll).

Therapeutic Function

Antiepileptic