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HomeProduct name listbamifylline hydrochloride

bamifylline hydrochloride

bamifylline hydrochloride Structural

What is bamifylline hydrochloride?

Originator

Bamifylline,ZYF Pharm Chemical

The Uses of bamifylline hydrochloride

Bronchodilator.

Manufacturing Process

A mixture of 100 kg of 8-benzyltheophilline, 36 L of N-ethylethanolamine, 300 L of 1,2-dichlorethane and 71 kg of sodium carbonate was refluxed for 24 hours. Then 36 L of N-ethylethanolamine was added and the reaction mixture was refluxed. After cooling to the mixture was added the water and hydrochloric acid. The organic phase was extracted with hydrochloric acid. The acidic phase was neutralized with sodium carbonate and the 7-(N-ethyl-N-β- hydroxyethylaminoethyl)-8-benzyltheophilline was extracted with dichloromethane. The solvent was evaporated and the free base of 7-(N-ethyl- N-β-hydroxyethylaminoethyl)-8-benzyltheophilline was dissolved in methanol. Hydrochloride of 7-(N-ethyl-N-β-hydroxyethylaminoethyl)-8-benzyltheophilline was obtained by addition to the solution the hydrochloric acid; yield 81%, melting point 185-186°C.

Therapeutic Function

Bronchodilator, Coronary vasodilator

Properties of bamifylline hydrochloride

Melting point: 185-186°

Safety information for bamifylline hydrochloride

Computed Descriptors for bamifylline hydrochloride

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