BAMIFYLLINE
- CAS NO.:2016-63-9
- Empirical Formula: C20H27N5O3
- Molecular Weight: 385.46
- MDL number: MFCD00867023
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 17:34:35
What is BAMIFYLLINE?
Originator
Bamifylline,ZYF Pharm Chemical
The Uses of BAMIFYLLINE
Bamifylline is a drug of the xanthine chemical class which acts as a selective adenosine A1 receptor antagonist.
The Uses of BAMIFYLLINE
Bronchodilator.
Definition
ChEBI: Bamifylline is an oxopurine.
Manufacturing Process
A mixture of 100 kg of 8-benzyltheophilline, 36 L of N-ethylethanolamine, 300 L of 1,2-dichlorethane and 71 kg of sodium carbonate was refluxed for 24 hours. Then 36 L of N-ethylethanolamine was added and the reaction mixture was refluxed. After cooling to the mixture was added the water and hydrochloric acid. The organic phase was extracted with hydrochloric acid. The acidic phase was neutralized with sodium carbonate and the 7-(N-ethyl-N-β- hydroxyethylaminoethyl)-8-benzyltheophilline was extracted with dichloromethane. The solvent was evaporated and the free base of 7-(N-ethyl- N-β-hydroxyethylaminoethyl)-8-benzyltheophilline was dissolved in methanol. Hydrochloride of 7-(N-ethyl-N-β-hydroxyethylaminoethyl)-8-benzyltheophilline was obtained by addition to the solution the hydrochloric acid; yield 81%, melting point 185-186°C.
Therapeutic Function
Bronchodilator, Coronary vasodilator
Properties of BAMIFYLLINE
Melting point: | 80-80.5° |
Boiling point: | 619.0±65.0 °C(Predicted) |
Density | 1.25 |
storage temp. | Hygroscopic, Refrigerator, under inert atmosphere |
solubility | Chloroform (Very Slightly), DMSO (Slightly), Methanol (Slightly) |
form | Solid |
pka | 14.73±0.10(Predicted) |
color | White to Pale Brown |
Stability: | Hygroscopic |
Safety information for BAMIFYLLINE
Computed Descriptors for BAMIFYLLINE
New Products
Tubulysin F Tubulysin E Tubulysin I 2,2-diethoxyethanethioamide 4,4-DIFLUOROPIPERIDINE 1-(1,1-Difluoroethyl)-2-fluorobenzene 4-(Benzyloxy)-3-bromophenylacetic Acid Methyl (R)-1-Boc-4,4-difluoropyrrolidine-2-carboxylate 2-(azetidin-3-ylidene)acetonitrile (hydrochloride) 2,2-Difluoropropanol 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol Calcium Sodium Phosphosilicate IH (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine Imeglimin Hydrochloride IH 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Latanoprostene Bunod Lubiprostone Magnesium Trisilicate Flame Retardant Zinc Borate methyl 3-fluoro-4- thiomorpholino phenylcarbamate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate 7-Methoxyquinoline-4-carboxylic acid 1H-Imidazole-4-carbonitrileRelated products of tetrahydrofuran
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