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HomeProduct name listBacitracin zinc

Bacitracin zinc

Synonym(s):Bacitracin zinc salt;Zinc bacitracin

  • CAS NO.:1405-89-6
  • Empirical Formula: C66H101N17O16SZn
  • Molecular Weight: 1486.06744
  • MDL number: MFCD28168035
  • EINECS: 215-787-8
  • Update Date: 2024-11-19 23:02:33
Bacitracin zinc Structural

What is Bacitracin zinc?

Description

Bacitracin zinc is a zinc complex of bacitracin, a polypeptide produced by the growth of an organism of the licheniformis group of Bacillus subtilis. The main components are Bacitracin A, B1 and B2.Bacitracin zinc has antibiotic activity against a variety of Gram-positive bacteria including staphylococci. The zinc complex adds stability to the component, making bacitracin zinc more stable compared to bacitracin.

Chemical properties

a white or pale brownish yellow powder; odourless or with a faint characteristic odour. Soluble in 900 parts of water and in 500 parts of ethanol (~750 g/l) TS; very slightly soluble in ether R. small amounts of bacitracin zinc are dissolved in petroleum jelly to create antibiotic ointments.

The Uses of Bacitracin zinc

Bacitracin zinc is a dephosphorylation of the C55-isoprenyl pyrophosphate interference for inhibition of cleavage of Tyr from Met-enkephalin with IC50 of 10 μM.

Indications

Bacitracin zinc is composed of a group of polypeptides with antibiotic activity against a variety of Gram-positive bacteria including staphylococci. It is used in the treatment of local infections, mainly infections of the skin, ear and eye.

brand name

Ziba (X Gen).

storage

Bacitracin zinc should be kept in a tightly closed container, protected from light, and stored at a temperature not exceeding 25 °C. If it is intended for parenteral administration, the container should be sterile and sealed so as to exclude microorganisms.

Properties of Bacitracin zinc

Melting point: 250 °C (dec.)
storage temp.  2-8°C
solubility  10 mM HCl: 5 mg/mL, clear, faintly yellow-green
form  Fine Crystalline Powder
color  White to light yellow-gray or beige
PH Shake 1.0 g with 10 mL of carbon-dioxide-free water R and filter; pH of the filtrate, 6.0-7.5.
Water Solubility  5.1 g/L (28 ºC)
Merck  13,938
EPA Substance Registry System Zinc bacitracin (1405-89-6)

Safety information for Bacitracin zinc

Computed Descriptors for Bacitracin zinc

InChIKey UCRLQOPRDMGYOA-FWMPYRTHSA-L

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