Azido-dPEG4-acid
- CAS NO.：1056024-94-2
- Empirical Formula: C9H17N3O5
- Molecular Weight: 247.25
- MDL number: MFCD23726617
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:00
What is Azido-dPEG4-acid?
Description
Azido-PEG3-acid is a crosslinker containing an azide(N3) group with a carboxylic acid (CO2H). The terminal carboxylic acid is reactive with primary amine groups in the presence of activators (e.g. EDC, or HATU) forming a stable amide bond. The azide group enables Click Chemistry. The hydrophilic PEG spacer increases solubility in aqueous media.
Definition
ChEBI: 3-{2-[2-(2-Azidoethoxy)ethoxy]ethoxy}propanoic acid is an organonitrogen compound.
Biological Activity
Azido-dPEG4-acid is a PEG-based PROTAC linker for the synthesis of BI-3663 (HY-111546), BI-4216 and BI-0319. It is also a non-cleavable ADC linker containing 3-unit PEG, which can be used to synthesize antibody drug conjugates (ADC).
in vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
Properties of Azido-dPEG4-acid
| solubility | DMSO : 100 mg/mL (404.45 mM; Need ultrasonic) |
| form | Liquid |
| color | Colorless to light yellow |
Safety information for Azido-dPEG4-acid
Computed Descriptors for Azido-dPEG4-acid
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