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HomeProduct name listAzetidine hydrochloride

Azetidine hydrochloride

Synonym(s):Trimethyleneimine hydrochloride

  • CAS NO.:36520-39-5
  • Empirical Formula: C3H8ClN
  • Molecular Weight: 93.55
  • MDL number: MFCD00191762
  • EINECS: 627-415-5
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-01-02 14:25:45
Azetidine hydrochloride Structural

What is Azetidine hydrochloride?

Chemical properties

White powder

The Uses of Azetidine hydrochloride

Azetidine hydrochloride is a four-membered ring nitrogen-containing heterocycle. Useful building block in the synthesis of polypeptides and other nitrogen containing compounds with potential biological properties.

The Uses of Azetidine hydrochloride

Basic building block for synthesizing azetidines.1,2

The Uses of Azetidine hydrochloride

Azetidine hydrochloride is a building block for azetidine synthesis and a pharmaceutical intermediate.

General Description

Azetidine derivatives are an essential class of aza-heterocyclic compounds with various biological activities and have been widely used as building blocks in pharmacological research. Although azetidine has the simplest structure, it is only commercially available in small quantities and at a high price. In addition, this compound is hard to synthesize for several reasons, such as cyclization of the four-membered ring, stability of the ring, and low boiling point[1].

References

[1] Jian Sun, Qi Sun, S. Gong. “A Novel Strategy for the Synthesis of Azetidine.” Advanced Materials Research 6 1 (2013): 135–138.

Properties of Azetidine hydrochloride

Melting point: >300 °C(lit.)
Flash point: 152 °C
storage temp.  Inert atmosphere,2-8°C
form  powder to crystal
color  White to Almost white
Water Solubility  Soluble in water (103.8°C at 760 mmHg).
Sensitive  Hygroscopic
InChI InChI=1S/C3H7N.ClH/c1-2-4-3-1;/h4H,1-3H2;1H
CAS DataBase Reference 36520-39-5(CAS DataBase Reference)

Safety information for Azetidine hydrochloride

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Azetidine hydrochloride

InChIKey HGQULGDOROIPJN-UHFFFAOYSA-N
SMILES C1CNC1.Cl

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