Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name listAtropine sulfate

Atropine sulfate

Synonym(s):α-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester;Atropine sulfate salt monohydrate;Tropine tropate

  • CAS NO.:55-48-1
  • Empirical Formula: 2C17H23NO3.H2O4S
  • Molecular Weight: 676.82
  • MDL number: MFCD00077268
  • EINECS: 200-235-0
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-25 23:13:37
Atropine sulfate Structural

What is Atropine sulfate?

The Uses of Atropine sulfate

anticholinergic agent

The Uses of Atropine sulfate

cholinergic receptor antagonist

What are the applications of Application

Atropine sulfate is a tropane alkaloid and muscarinic acetylcholine receptor antagonist

brand name

Atrophate [Veterinary] (Schering-Plough Animal Health); Atropisol (Ciba Vision, US Ophthalmics); Isopto Atropine (Alcon).

General Description

Atropine sulfate (Atropisol)is prepared by neutralizing atropine in acetone or ethersolution with an alcoholic solution of sulfuric acid, withcare used to prevent hydrolysis. The salt occurs as colorlesscrystals or as a white, crystalline powder. It is efflorescentin dry air and should be protected from light to preventdecomposition.
Atropine sulfate is freely soluble in water (1:0.5), in alcohol(1:5, 1:2.5 at boiling point), and in glycerin (1:2.5).Aqueous solutions are not very stable, although solutionsmay be sterilized at 120°C (15 lb pressure) in an autoclave if the pH is kept below 6. Sterilization probably is besteffected by the use of aseptic techniques and a bacteriologicalfilter. It has been suggested that no more than a 30-daysupply of an aqueous solution should be made and that forsmall quantities the best procedure is to use hypodermictablets and sterile distilled water. Kondritzer andZvirblis have studied the kinetics of alkaline and protoncatalyzedhydrolyses of atropine in aqueous solution. Theregion of maximal stability lies between pH 3 and approximately5. They have also proposed an equation to predictthe half-life of atropine undergoing hydrolysis at constantpH and temperature.

Clinical Use

Atropine may be used to treat some types of arrhythmias. Itincreases the heart rate by blocking the effects of ACh on thevagus. In this context, it is used to treat certain reversible bradyarrhythmiasthat may accompany acute myocardial infarction.It is also used as an adjunct to anesthesia to protect againstbradycardia, hypotension, and even cardiac arrest induced bythe skeletal muscle relaxant succinylcholine chloride.
Another use for atropine sulfate emerged following thedevelopment of the organophosphates, which are potent inhibitorsof AChE. Atropine is a specific antidote to preventthe muscarinic effects of ACh accumulation, such as vomiting,abdominal cramps, diarrhea, salivation, sweating, bronchoconstriction,and excessive bronchial secretions. It isused intravenously but does not protect against respiratoryfailure caused by depression of the respiratory center andthe muscles of respiration.

Safety Profile

Poison by subcutaneous, intravenous, and intraperitoneal routes. Moderately toxic by ingestion. Human (child) pulmonary system effects by ingestion. Human systemic effects: decreased body temperature, cardiac arrhythmias. An experimental teratogen. Other experimental reproductive effects. See also ATROPINE. When heated to decomposition it emits very toxic fumes of NO,xand SOx.

Veterinary Drugs and Treatments

The principal veterinary indications for systemic atropine include:
!!Preanesthetic to prevent or reduce secretions of the respiratory tract
!!Treat sinus bradycardia, sinoatrial arrest, and incomplete AV block
!!Differentiate vagally-mediated bradycardia for other causes
!!As an antidote for overdoses of cholinergic agents (e.g., physostigmine, etc.)
!!As an antidote for organophosphate, carbamate, muscarinic mushroom, blue-green algae intoxication
!!Hypersialism
!!Treatment of bronchoconstrictive disease

Properties of Atropine sulfate

Melting point: 189-192 °C (A)(lit.)
Boiling point: 135 °C
Density  1.1172 (rough estimate)
refractive index  1.6900 (estimate)
storage temp.  0-6°C
solubility  Soluble in DMSO
form  Solid
color  Crystals
CAS DataBase Reference 55-48-1(CAS DataBase Reference)
EPA Substance Registry System Atropine sulfate (55-48-1)

Safety information for Atropine sulfate

Computed Descriptors for Atropine sulfate

InChIKey HOBWAPHTEJGALG-AADVZIIPNA-N

Abamectin manufacturer

Humble Healthcare Limited

1Y
Phone:+91-8006400378
Whatsapp: +91 8006400378
product: 55-48-1 / 17108-73-5 Atropine Sulfate 99%
Inquiry

Inga Pharmaceuticals

1Y
Phone:+91-2228202932
product: 55-48-1 / 17108-73-5 99%
Inquiry

ASolution Pharmaceuticals Pvt Ltd

1Y
Phone:+919028098510
Whatsapp: +91- 9028098510
product: 55-48-1 / 17108-73-5 98%
Inquiry

Alchem International Pvt Ltd

1Y
Phone:+91-1126809882
product: Atropine Sulfate 55-48-1 / 17108-73-5 98%
Inquiry

Saurav Chemicals Ltd

1Y
Phone:+91-1725054817
product: Atropine Sulfate 55-48-1 / 17108-73-5 99%
Inquiry

Flowchem Pharma Pvt Ltd

1Y
Phone:+91-9845055636
Whatsapp: +91- 9845055636
product: Atropine Sulfate 55-48-1 / 17108-73-5 98%
Inquiry

Related products of tetrahydrofuran

You may like

  • 55-48-1 / 17108-73-5 Atropine Sulfate 99%
    55-48-1 / 17108-73-5 Atropine Sulfate 99%
    55-48-1 / 17108-73-5
    View Details
  • 55-48-1 / 17108-73-5 99%
    55-48-1 / 17108-73-5 99%
    55-48-1 / 17108-73-5
    View Details
  • 55-48-1 / 17108-73-5 98%
    55-48-1 / 17108-73-5 98%
    55-48-1 / 17108-73-5
    View Details
  • Atropine Sulfate 55-48-1 / 17108-73-5 98%
    Atropine Sulfate 55-48-1 / 17108-73-5 98%
    55-48-1 / 17108-73-5
    View Details
  • Atropine Sulfate 55-48-1 / 17108-73-5 99%
    Atropine Sulfate 55-48-1 / 17108-73-5 99%
    55-48-1 / 17108-73-5
    View Details
  • Atropine Sulfate 55-48-1 / 17108-73-5 98%
    Atropine Sulfate 55-48-1 / 17108-73-5 98%
    55-48-1 / 17108-73-5
    View Details
  • Atropine sulfate 95% CAS 55-48-1
    Atropine sulfate 95% CAS 55-48-1
    55-48-1
    View Details
  • 95-54-5 99%
    95-54-5 99%
    95-54-5
    View Details
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.