ASP-ARG-VAL-TYR-ILE-HIS-PRO
- CAS NO.:51833-78-4
- Empirical Formula: C41H62N12O11
- Molecular Weight: 899
- MDL number: MFCD00153513
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-01 18:09:03
What is ASP-ARG-VAL-TYR-ILE-HIS-PRO?
The Uses of ASP-ARG-VAL-TYR-ILE-HIS-PRO
Angiotensin (1-7) can be used in biological study and engineering or chemical process of mechanisms of peptide oxidation by hydroxyl radicals.
What are the applications of Application
Angiotensin fragment 1-7 acetate salt is an angiotensin I metabolite that is an AT2 receptor activator
What are the applications of Application
A-779 is a selective angiotensin-(1-7) antagonist
Definition
ChEBI: Ile(5)-angiotensin II (1-7) is an angiotensin compound consisting of the linear heptapeptide sequence L-Asp-L-Arg-L-Val-L-Tyr-L-Ile-L-His-L-Pro. It has a role as a vasodilator agent. It is a tautomer of an Ile(5)-angiotensin II (1-7) dizwitterion.
Biological Activity
ang-(1-7) (h - asp - arg - val - tyr - ile - his - pro - oh) is an endogenous peptide fragment that can be produced from ang i or ang ii via endo- or carboxy-peptidases respectively[1].as described for ang ii, ang-(1-7) also has a broad range of effects in different organs and tissues and goes beyond its initially described cardiovascular and renal actions. those effects are mediated by mas and can counter-regulate most of the deleterious effects of ang ii. the interaction ang-(1-7)/mas regulates different signaling pathways, such as pi3k (phosphoinositide 3-kinase)/akt and erk (extracellular signal-regulated kinase) pathways and involves downstream effectors such as no, foxo1 (forkhead box o1) and cox-2 (cyclo-oxygenase-2). through these mechanisms, ang-(1-7) is able to improve pathological conditions including fibrosis and inflammation in organs such as lungs, liver and kidney. [2]in addition, this heptapeptide has positive effects on metabolism, increasing the glucose uptake and lipolysis while decreasing insulin resistance and dyslipidemia. ang-(1-7) is also able to improve cerebroprotection against ischemic stroke, besides its effects on learning and memory. the reproductive system can also be affected by ang-(1-7) treatment, with enhanced ovulation, spermatogenesis and sexual steroids synthesis. finally, ang-(1-7) is considered a potential anti-cancer treatment since it is able to inhibit cell proliferation and angiogenesis.[2]fig. 1: formula of angiotensin (1-7)fig. 2: cascade of the processing of angiotensin peptides and their interaction with at1 and at1-7 receptor systems.
Biochem/physiol Actions
Angiotensin I metabolite that is an AT2 receptor agonist.
storage
Store at -20°C
References
1. Santos et al (2000) Angiotensin-(1-7): an update. Regul.Pept. 91 45.2. Danielle G. P., Thiago V., Robson A. S. Angiotensin-(1-7): beyond the cardio-renal actions. Clinical Science (2013) 124, (443–456)
Properties of ASP-ARG-VAL-TYR-ILE-HIS-PRO
Melting point: | >202°C (dec.) |
Density | 1.47±0.1 g/cm3(Predicted) |
storage temp. | −20°C |
solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly, Sonicated) |
form | powder |
pka | 3.29±0.20(Predicted) |
color | White to Off-White |
Water Solubility | Soluble to 1 mg/ml in water |
Safety information for ASP-ARG-VAL-TYR-ILE-HIS-PRO
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. P405:Store locked up. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P501:Dispose of contents/container to..… |
Computed Descriptors for ASP-ARG-VAL-TYR-ILE-HIS-PRO
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