ASIALOGANGLIOSIDE-GM2
Synonym(s):GA2 Ganglioside;Gangliotriosyl ceramide
- CAS NO.：35960-33-9
- Empirical Formula: C56H104N2O18
- Molecular Weight: 1093.42756
- MDL number: MFCD00131129
- Update Date: 2023-05-18 11:31:07
What is ASIALOGANGLIOSIDE-GM2?
Description
Ganglioside GM2 asialo (asialo- GM2) is a glycosphingolipid containing three monosaccharide residues and a fatty acid of variable chain length but lacking the sialic acid residue present on ganglioside M2. Asialo-GM2 levels are low-to-undetectable in normal human brain, but it accumulates in the brain of patients with Tay-Sachs and Sandhoff disease, which are neurodegenerative disorders characterized by deficiency of lysosomal β-hexosaminidase A and B, respectively. It also binds to various bacteria, including Pseudomonas isolates derived from cystic fibrosis patients. Asialo-GM2 mixture contains ganglioside GM2 asialo molecular species with fatty acyl chains of variable lengths. [Matreya, LLC. Catalog No. 1512]
The Uses of ASIALOGANGLIOSIDE-GM2
Ganglioside GM2, Asialo is a semisynthetic ganglioside.
What are the applications of Application
Ganglioside GM2, Asialo is a semisynthetic ganglioside
General Description
Gangliosides are major constituents of neuronal cell membranes and endoplasmic reticulum; contain a sialated polysaccharide chain linked to ceramide through a β-glycosidic linkage; for classification of gangliosides see Svennerholm, L., et al. (eds.), Structure and Function of Gangliosides, New York, Plenum, 1980.
Biochem/physiol Actions
Degraded form of Asialoganglioside-GM1 ganglioside.
Properties of ASIALOGANGLIOSIDE-GM2
| storage temp. | −20°C |
| solubility | Chloroform:Methanol:Water (2:1:0.1): Soluble |
| form | lyophilized powder |
Safety information for ASIALOGANGLIOSIDE-GM2
Computed Descriptors for ASIALOGANGLIOSIDE-GM2
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