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HomeProduct name listASIALOGANGLIOSIDE-GM2

ASIALOGANGLIOSIDE-GM2

Synonym(s):GA2 Ganglioside;Gangliotriosyl ceramide

  • CAS NO.:35960-33-9
  • Empirical Formula: C56H104N2O18
  • Molecular Weight: 1093.42756
  • MDL number: MFCD00131129
  • Update Date: 2023-05-18 11:31:07
ASIALOGANGLIOSIDE-GM2 Structural

What is ASIALOGANGLIOSIDE-GM2?

Description

Ganglioside GM2 asialo (asialo- GM2) is a glycosphingolipid containing three monosaccharide residues and a fatty acid of variable chain length but lacking the sialic acid residue present on ganglioside M2. Asialo-GM2 levels are low-to-undetectable in normal human brain, but it accumulates in the brain of patients with Tay-Sachs and Sandhoff disease, which are neurodegenerative disorders characterized by deficiency of lysosomal β-hexosaminidase A and B, respectively. It also binds to various bacteria, including Pseudomonas isolates derived from cystic fibrosis patients. Asialo-GM2 mixture contains ganglioside GM2 asialo molecular species with fatty acyl chains of variable lengths. [Matreya, LLC. Catalog No. 1512]

The Uses of ASIALOGANGLIOSIDE-GM2

Ganglioside GM2, Asialo is a semisynthetic ganglioside.

What are the applications of Application

Ganglioside GM2, Asialo is a semisynthetic ganglioside

General Description

Gangliosides are major constituents of neuronal cell membranes and endoplasmic reticulum; contain a sialated polysaccharide chain linked to ceramide through a β-glycosidic linkage; for classification of gangliosides see Svennerholm, L., et al. (eds.), Structure and Function of Gangliosides, New York, Plenum, 1980.

Biochem/physiol Actions

Degraded form of Asialoganglioside-GM1 ganglioside.

Properties of ASIALOGANGLIOSIDE-GM2

storage temp.  −20°C
solubility  Chloroform:Methanol:Water (2:1:0.1): Soluble
form  lyophilized powder

Safety information for ASIALOGANGLIOSIDE-GM2

Computed Descriptors for ASIALOGANGLIOSIDE-GM2

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