Arteether
- CAS NO.:75887-54-6
- Empirical Formula: C17H28O5
- Molecular Weight: 312.4
- MDL number: MFCD00869355
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 20:33:22
What is Arteether?
Description
Arteether reached the market in the Netherlands as a solution in sesame oil, administered by i.m. injection, for the treatment of severe malaria infections in children and adolescents. Artheether, a sesquiterpene acetal with an endoperoxide bridge, is an ether derivative of the naturally occuring compound artemisinin, the active component of Chinese herbal remedies. As the other structural analogs of artemisinin, such as artesunate or artemether, it acts rapidly against Plasmodium, the parasite responsible for the disease, during the early blood stage of its development. It also exhibits a gametocytocidal activity against Plasmodium falciparum, reducing its potential for transmission. Because the only controlled clinical studies had been performed in children and adolescents, this new antimalarial drug was only approved for young patients. Further studies in adults treated with 150 mg i.m. artemotil, once daily for three consecutive days, indicated that the drug was efficient, rapidly acting (parasite clearance time meanly 38 h) and well tolerated. A new promising achievement in the regression of malaria is the combination of artemisinin derivatives with other long-lived antimalarials as mefloquine or pyrimethamine/sulfa.
Chemical properties
White Crystalline Solid
Originator
Central Drug Research Institute (India)
The Uses of Arteether
Derivative of Artemisinin. Antimalarial
Background
Artemotil, also known as β-arteether, is a semi-synthetic derivative of artemisinin and a fast acting blood schizonticide specifically indicated for the treatment of chloroquine-resistant Plasmodium falciparum malaria and cerebral malaria cases.
What are the applications of Application
Arteether is derivative of Artemisinin and an antimalarial.
Definition
ChEBI: Artemotil is an artemisinin derivative.
brand name
Artemotil
Metabolism
Not Available
Properties of Arteether
Melting point: | 80-820C |
alpha | D21 +154.5° (c = 1.0 in CHCl3) |
Boiling point: | 372.4±42.0 °C(Predicted) |
Density | 1.16±0.1 g/cm3(Predicted) |
storage temp. | Sealed in dry,2-8°C |
solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
form | Solid |
color | White |
CAS DataBase Reference | 75887-54-6 |
Safety information for Arteether
Signal word | Danger |
Pictogram(s) |
Flame Flammables GHS02 Skull and Crossbones Acute Toxicity GHS06 |
GHS Hazard Statements |
H226:Flammable liquids |
Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233:Keep container tightly closed. P240:Ground/bond container and receiving equipment. P241:Use explosion-proof electrical/ventilating/lighting/…/equipment. P242:Use only non-sparking tools. P243:Take precautionary measures against static discharge. P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P370+P378:In case of fire: Use … for extinction. P405:Store locked up. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P403+P235:Store in a well-ventilated place. Keep cool. |
Computed Descriptors for Arteether
Abamectin manufacturer
Ralington Pharma
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