ARS-1620

CAS NO.：1698055-85-4
Empirical Formula: C21H17ClF2N4O2
Molecular Weight: 430.84
MDL number: MFCD31619312
Update Date: 2024-10-30 21:47:27

What is ARS-1620?

The Uses of ARS-1620

ARS-1620, is an atropisomeric selective KRASG12C inhibitor with desirable pharmacokinetics.

Definition

ChEBI: ARS-1620 is a qinazoline derivative carrying chloro and fluoro substituents at positions 6 and 8 respectively, a 2-fluoro-6-hydroxyphenyl group at position 7, and a 4-(prop-2-enoyl)piperazin-1-yl group at position 4. A potent, selective, and orally bioavailable covalent KRAS-G12C inhibitor, it inhibits the protein coding gene KRAS (Kirsten rat sarcoma virus) with high potency in cells and animals. It has a role as an inhibitor, an antiviral agent and an antineoplastic agent.

Properties of ARS-1620

Boiling point:	614.7±55.0 °C(Predicted)
Density	1.434±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO:70.0(Max Conc. mg/mL);162.47(Max Conc. mM)
form	A solid
pka	6.03±0.35(Predicted)
color	Off-white to light yellow

Safety information for ARS-1620

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.