ARRY-424704, ARRY-704
- CAS NO.:869357-68-6
- Empirical Formula: C16H17FIN3O4
- Molecular Weight: 461.23
- MDL number: MFCD18384989
- EINECS: 642-441-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-01 18:44:47
What is ARRY-424704, ARRY-704?
Description
AZD 8330 is a selective allosteric inhibitor of MEK1/2 (IC50 = 7 nM). It blocks phosphorylation of ERK1/2 and inhibits proliferation of certain cancer cells. AZD 8330 is orally bioavailable, inhibits ERK phosphorylation in vivo, and reduces tumor growth in a Calu-6 nude rat xenograft model.
The Uses of ARRY-424704, ARRY-704
AZD8330 is an orally active and selective MEK inhibitor.
What are the applications of Application
AZD8330 is an antineoplastic selective MEK inhibitor
Definition
ChEBI: 2-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxo-3-pyridinecarboxamide is a pyridinecarboxamide. It is functionally related to a nicotinamide.
References
1. feng k, wang c, zhou h, yang j, dong l, zhou k, et al. [effect of erk1/2 inhibitor azd8330 on human burkitt's lymphoma cell line raji cells and its mechanism]. zhonghua xue ye xue za zhi 2015,36:148-152.2. cohen rb, aamdal s, nyakas m, cavallin m, green d, learoyd m, et al. a phase i dose-finding, safety and tolerability study of azd8330 in patients with advanced malignancies. eur j cancer 2013,49:1521-1529.
Properties of ARRY-424704, ARRY-704
Density | 1.732 |
storage temp. | Store at -20°C |
solubility | ≥23.05 mg/mL in DMSO; insoluble in H2O; ≥46.1 mg/mL in EtOH |
form | solid |
pka | 14.31±0.10(Predicted) |
color | Off-white to pink |
Safety information for ARRY-424704, ARRY-704
Computed Descriptors for ARRY-424704, ARRY-704
New Products
Bromine 99.5% AR (4 x 500ml) Fehling's Solution No. B Amino Acid Kit of 23 items set Ammonium Molybdate Reagent Solution Beam's Reagent Solution Ehrlich's Reagent For detection of urobillinogen 4-((2-isopropoxyethoxy)methyl)phenol 4-Hydroxy Carbazole Amino Salicylic Acid. U.S.P. 1,2,3,4-Tetrahydrocarbazol-4-one 2 – Methoxy – 5- Sulfamoyl Benzoic acid Acetone Isobutryl oxime ester Curcuma aromatica Oil Curry leaf Extract Terminalia bellirica Extract Aloe vera extract 200x Withania somnifera (Ashwagandha Extract) Citrus bioflavonoids Extract 5-Nitrosalicylaldehyde 5-(Difluoromethoxy)-2-Mercapto-1H-Benzimidazole- IP/BP/ Ethyl 3-(Pyridin-2-Ylamino)Propanoate Bilastine -IP/BP/ Cypermethric Acid Chloride Methyl Di Chloride (Mdc)Related products of tetrahydrofuran
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