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HomeProduct name listARRY-424704, ARRY-704

ARRY-424704, ARRY-704

  • CAS NO.:869357-68-6
  • Empirical Formula: C16H17FIN3O4
  • Molecular Weight: 461.23
  • MDL number: MFCD18384989
  • EINECS: 642-441-7
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-01 18:44:47
ARRY-424704, ARRY-704 Structural

What is ARRY-424704, ARRY-704?

Description

AZD 8330 is a selective allosteric inhibitor of MEK1/2 (IC50 = 7 nM). It blocks phosphorylation of ERK1/2 and inhibits proliferation of certain cancer cells. AZD 8330 is orally bioavailable, inhibits ERK phosphorylation in vivo, and reduces tumor growth in a Calu-6 nude rat xenograft model.

The Uses of ARRY-424704, ARRY-704

AZD8330 is an orally active and selective MEK inhibitor.

What are the applications of Application

AZD8330 is an antineoplastic selective MEK inhibitor

Definition

ChEBI: 2-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxo-3-pyridinecarboxamide is a pyridinecarboxamide. It is functionally related to a nicotinamide.

References

1. feng k, wang c, zhou h, yang j, dong l, zhou k, et al. [effect of erk1/2 inhibitor azd8330 on human burkitt's lymphoma cell line raji cells and its mechanism]. zhonghua xue ye xue za zhi 2015,36:148-152.2. cohen rb, aamdal s, nyakas m, cavallin m, green d, learoyd m, et al. a phase i dose-finding, safety and tolerability study of azd8330 in patients with advanced malignancies. eur j cancer 2013,49:1521-1529.

Properties of ARRY-424704, ARRY-704

Density  1.732
storage temp.  Store at -20°C
solubility  ≥23.05 mg/mL in DMSO; insoluble in H2O; ≥46.1 mg/mL in EtOH
form  solid
pka 14.31±0.10(Predicted)
color  Off-white to pink

Safety information for ARRY-424704, ARRY-704

Computed Descriptors for ARRY-424704, ARRY-704

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