Arbidol hydrochloride

Description

Umifenovir is a broad-spectrum antiviral agent. It inhibits the replication of H5N1 influenza (IC₅₀ = 30 μg/ml) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro (IC₅₀ = 3.537 μM). Umifenovir inhibits entry of hepatitis C virus (HCV) pseudoparticles in Huh7 cells (IC₅₀ = 6 μg/ml) and inhibits Zika virus protein synthesis in Vero cells. In vivo, umifenovir (45 mg/kg) reduces the formation of influenza-induced lung lesions in ferrets.

Chemical properties

Off White to Pale Yellow Solid

The Uses of Arbidol hydrochloride

Arbidol hydrochloride (ARB) is a small monocular compound. It is used to prevent severe pneumonia and virus-associated cytokine dysregulation induced by influenza viruses (IFV). ARB also possesses some immunomodulatory properties, including the effects of interferon induction and macrophage activation.
Arbidol is a broad-spectrum antiviral that has demonstrated activity against a number of enveloped and non-enveloped viruses, and is used clinically to treat influenza. Arbidol inhibits viral entry into host cell and stimulates immune response. Arbidol inhibits fusion between the viral capsid and the cell membrane of the target cell, thus preventing viral entry.

The Uses of Arbidol hydrochloride

Arbidol is an antiviral treatment for influenza infection.

What are the applications of Application

Arbidol Hydrochloride is an antiviral agent

Biochem/physiol Actions

Arbidol hydrochloride (ARB) is a small monocular compound. It is used to prevent severe pneumonia and virus-associated cytokine dysregulation induced by influenza viruses (IFV). ARB also possesses some immunomodulatory properties, including the effects of interferon induction and macrophage activation.

storage

Store at -20°C

References

1) Blasing?et al.?(2014), Arbidol as a broad-spectrum antiviral: an update; Antiviral Res,?107?84 2) Boriskin?et al. (2008) Arbidol: a broad-spectrum antiviral compound that blocks viral fusion; Curr. Med. Chem.,?15?997 3) Brooks?et al.?(2012) Antiviral activity of Arbidol, a broad-spectrum drug for use against respiratory viruses, varies according to test conditions; J. Med. Virol.,?84?170 4) Leneva?et al.?(2009)?Characteristics of Arbidol-resistant mutants of influenza virus: Implications for the mechanism of anti-influenza action of arbidol; Antiviral Res.,?81?132 5) Wang?et al.?(2020)?The anti-influenza drug, arbidol, is an efficient inhibitor of SARS-CoV-2 in vitro; Cell Discov.,?6?28 6) Vankadari?(2020)?Arbidol: A Potential Antiviral Drug for the Treatment of SARS-CoV-2 by Blocking Trimerization of the Spike Glycoprotein; Int. J. Antimicrob. Agents, 56 105998