Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name listARACHIDONAMIDE

ARACHIDONAMIDE

ARACHIDONAMIDE Structural

What is ARACHIDONAMIDE?

The Uses of ARACHIDONAMIDE

Arachidonamide (20:4, n-6) is a weak cannabinoid CB1 and CB2 agonist.

What are the applications of Application

Arachidonamide (20:4, n-6) is a weak cannabinoid CB1 and CB2 agonist

Definition

ChEBI: Arachidonoyl amine is a primary fatty amide resulting from the formal condensation of the carboxy group of arachidonic acid with ammonia. It has a role as a cannabinoid receptor agonist. It is functionally related to an arachidonic acid.

Biological Activity

arachidonoyl amide is a cb1 receptor agonist [1]. the cannabinoid receptor type 1, abbreviated as cb1, is a g protein-coupled cannabinoid receptor expressed primarily in the central and peripheral nervous system. cb1 receptor has been implicated in maintaining the homeostasis in health and disease. overexpression of cb1 receptor has been found in human hepatocellular carcinoma tumor samples and other human prostate cancer cells [2].arachidonoyl amide is an analog of anandamide (aea) that lacks the hydroxyethyl moiety. it was hydrolyzed by faah more effectively than aea but exhibited significantly weaker binding to the human cb1 receptor with a ki of 9.6 μm [1]. arachidonoyl amide exhibited similar binding and translocation into cells via the aea transporter compared to aea. arachidonoyl amide inhibited [3h]-aea uptake into human astrocytoma cells with an ic50 of 9 μm [3].

References

[1] felder c c, briley e m, axelrod j, et al. anandamide, an endogenous cannabimimetic eicosanoid, binds to the cloned human cannabinoid receptor and stimulates receptor-mediated signal transduction[j]. proceedings of the national academy of sciences, 1993, 90(16): 7656-7660.
[2] pertwee r g. the diverse cb1 and cb2 receptor pharmacology of three plant cannabinoids: δ9‐tetrahydrocannabinol, cannabidiol and δ9‐tetrahydrocannabivarin[j]. british journal of pharmacology, 2008, 153(2): 199-215.
[3] piomelli, d. ,beltramo, m.,glasnapp, s., et al. structural determinants for recognition and translocation by the anandamide transporter. proceedings of the national academy of sciences of the united states of america 96, 5802-5807 (1999).

Properties of ARACHIDONAMIDE

Boiling point: 462.9±34.0 °C(Predicted)
Density  0.908±0.06 g/cm3(Predicted)
storage temp.  -20°C
solubility  ≤10mg/ml in ethanol;10mg/ml in DMSO;10mg/ml in dimethyl formamide
pka 16.54±0.40(Predicted)
form  Colorless oil.

Safety information for ARACHIDONAMIDE

Computed Descriptors for ARACHIDONAMIDE

Related products of tetrahydrofuran

You may like

  • 1-Methyl-6-oxo-1,6-dihydropyridazine-3-carbonitrile 98%
    1-Methyl-6-oxo-1,6-dihydropyridazine-3-carbonitrile 98%
    99903-60-3
    View Details
  • 88491-46-7 98%
    88491-46-7 98%
    88491-46-7
    View Details
  • 1823368-42-8 98%
    1823368-42-8 98%
    1823368-42-8
    View Details
  • 2-(3-(tert-butyl)phenoxy)-2-methylpropanoic acid 1307449-08-6 98%
    2-(3-(tert-butyl)phenoxy)-2-methylpropanoic acid 1307449-08-6 98%
    1307449-08-6
    View Details
  • Ethyl 3-(furan-2-yl)-3-hydroxypropanoate 25408-95-1 98%
    Ethyl 3-(furan-2-yl)-3-hydroxypropanoate 25408-95-1 98%
    25408-95-1
    View Details
  • 2-Chloro-5-fluoro-1-methoxy-3-methylbenzene 98%
    2-Chloro-5-fluoro-1-methoxy-3-methylbenzene 98%
    1805639-70-6
    View Details
  • 1784294-80-9 98%
    1784294-80-9 98%
    1784294-80-9
    View Details
  • Lithium Clavulanate
    Lithium Clavulanate
    61177-44-4
    View Details
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.