AM 630
Synonym(s):6-Iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl](4-methoxyphenyl)methanone;AM 630;Iodopravadoline
- CAS NO.:164178-33-0
- Empirical Formula: C23H25IN2O3
- Molecular Weight: 504.36
- MDL number: MFCD01861183
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-30 15:45:59
What is AM 630?
The Uses of AM 630
AM 630 acts as a potential CB2 receptor cannabinoid antagonist with application towards human lung cancer treatment and angiogenesis induction.
The Uses of AM 630
AM630 has been used:
- as a cannabinoid 2(CB2) inhibitor to study the analgesic effect exerted by polysaccharopeptide from?Trametes versicolor (TPSP).
- as a CB2 antagonist along with β-caryophyllene (BCP) to study its effects on re-epithilialization of fibroblast cells.
- as a CB2 antagonist to study its interaction with 17-β-estradiol in primary human osteoblasts.
What are the applications of Application
AM-630 is a selective CB2 receptor antagonist that binds to CB1 and CB2 receptors
Definition
ChEBI: [6-iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-3-indolyl]-(4-methoxyphenyl)methanone is a N-acylindole.
Biological Activity
CB 2 antagonist/inverse agonist (K i = 31.2 nM) that displays 165-fold selectivity over CB 1 receptors. Behaves as a weak partial/inverse agonist at CB 1 receptors.
Biochem/physiol Actions
AM630 is an aminoalkylindole and acts as a competitive antagonist of CP 55,940 and WIN 55,212-2. It also behaves as a competitive antagonist of anandamide and (R)-(+)-arachidonyl-1′-hydroxy-2′-propylamide (AM356).
storage
Desiccate at +4°C
References
1. ross r a, brockie h c, stevenson l a, et al. agonist-inverse agonist characterization at cb1 and cb2 cannabinoid receptors of l759633, l759656 and am630. british journal of pharmacology, 1999, 126(3): 665-672. 2. patil m, patwardhan a, salas m m, et al. cannabinoid receptor antagonists am251 and am630 activate trpa1 in sensory neurons. neuropharmacology, 2011, 61(4): 778-788.
Properties of AM 630
Boiling point: | 605.9±55.0 °C(Predicted) |
Density | 1.49±0.1 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | DMSO: >5mg/mL |
pka | 6.98±0.10(Predicted) |
form | powder |
color | white to beige |
Safety information for AM 630
Signal word | Warning |
Pictogram(s) |
Environment GHS09 |
GHS Hazard Statements |
H410:Hazardous to the aquatic environment, long-term hazard |
Precautionary Statement Codes |
P273:Avoid release to the environment. P501:Dispose of contents/container to..… |
Computed Descriptors for AM 630
New Products
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