antibiotic 1233A

Synonym(s):(2E, 4E, 7R)-11-[(2R,3R)-3-(Hydroxymethyl)-4-oxooxetan-2-yl]-3,5,7-trimethylundeca-2,4-dienoic acid;Antibiotic 1233A;F-244;L-659,699

CAS NO.：29066-42-0
Empirical Formula: C18H28O5
Molecular Weight: 324.41
SAFETY DATA SHEET (SDS)
Update Date: 2025-12-23 13:58:55

What is antibiotic 1233A?

Description

Hymeglusin (29066-42-0) is an inhibitor of eukaryotic mevalonate biosynthesis via inhibition of HMG-CoA synthase, IC50=0.12 μM.1 Acts via covalent modification of the active site Cys129.1,2 Inhibits cholesterol biosynthesis in rats (45% at 25 mg/Kg).1 Also inhibits bacterial HMG-CoA synthase.3 Inhibits dengue virus replication.4

The Uses of antibiotic 1233A

Hymeglusin is an irreversible HMG-CoA synthase inhibitor.

What are the applications of Application

Hymeglusin is an irreversible HMG-CoA synthase inhibitor

Definition

ChEBI: Hymeglusin is a long-chain fatty acid.

Storage

+4°C

References

1) Greenspan et al. (1987), Inhibition of hydroxymethylglutaryl-coenzyme A synthase by L-659,699; Proc. Natl. Acad. Sci. USA, 84 7488 2) Tomoda et al. (2004), Binding site for fungal beta-lactone hymeglusin on cytosolic 3-hydroxy-3-methylglutaryl coenzyme A synthase; Biochem. Biophys. Acta, 1636 22 3) Skaff et al. (2012), Biochemical and structural basis for inhibition of Enterococcis faecalis hydroxymethylglutaryl-CoA synthase, mvaS, by hymeglusin; Biochemistry, 51 4713 4) Rothwell et al. (2009), Cholesterol biosynthesis modulation regulates dengue viral replication; Virology, 389 8

Properties of antibiotic 1233A

Boiling point:	516.6±15.0 °C(Predicted)
Density	1.101±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	DMSO: soluble
form	powder
pka	4.98±0.33(Predicted)
color	White
Stability:	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.