Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name listAmpicillin sodium

Ampicillin sodium

Synonym(s):Ampicillin sodium salt;Ampicillin, Sodium Salt - CAS 69-52-3 - Calbiochem;Ampicillin, Sodium Salt, Sterile, Tissue Culture Grade - CAS 69-52-3 - Calbiochem;Ampicillin, Sodium Salt, Sterile-Filtered Aqueous Solution, Cell Culture Tested - CAS 69-52-3 - Calbiochem;Xylose Lysine Deoxycholate Agar

  • CAS NO.:69-52-3
  • Empirical Formula: C16H20N3NaO4S
  • Molecular Weight: 373.4
  • MDL number: MFCD00064313
  • EINECS: 200-708-1
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-21 15:02:05
Ampicillin sodium Structural

What is Ampicillin sodium?

Chemical properties

White or almost white powder, hygroscopic.

The Uses of Ampicillin sodium

Ampicillin sodium salt is a reagent for transformed cells expressing beta-lactamase. It acts as a structural analogue of acyl-D-alanyl-D-alanine, acylates the transpeptidase enzyme and prevents the cross-linking of the peptidoglycan of the cell wall necessary for the growth of the bacterium.

The Uses of Ampicillin sodium

Penicillin antibacterial.

The Uses of Ampicillin sodium

diuretic, anti-hypertensive

What are the applications of Application

Ampicillin sodium salt, cell culture grade is a widely used cell culture antibiotic

Definition

ChEBI: Ampicillin sodium is an organic sodium salt. It contains an ampicillin(1-).

brand name

Polycillin-N (Bristol-Myers Squibb).

General Description

Chemical structure: ?-lactam

Biological Activity

ampicillin sodium is a competitive inhibitor of the enzyme transpeptidase with ic50 value of 1.8 μg/ml [1].ampicillin is a β-lactam antibiotic that kills bacteria by inhibiting transpeptidase reactions. transpeptidase is involved in the final stages of cell wall biosynthesis and inhibition of it ultimately leads to cell lysis [1].in e. coli 146 cells treated with ether, ampicillin showed no significant inhibition on the transpeptidase reaction at concentrations below 0.5 μg/ml, but exhibited 50% inhibition at the concentration of 1.8 μg/ml. in e. coli 146 cells, the minimal inhibitory concentration (mic) of ampicillin was 3.1 μg/ml [1]. in e. coli and s. typhi, ampicillin and epicillin at concentrations close to mic values killed bacteria at slower rates than amoxycillin [2].in experimental mouse infections, oral or subcutaneous treatment of ampicillin at the dose of 0.2 ml/20 g was significantly more effective than epicillin and amoxycillin against the majority of infections [2].[1]. moore b a, jevons s, brammer k w. inhibition of transpeptidase activity in escherichia coli by thienamycin. antimicrobial agents and chemotherapy, 1979, 15(6): 831-833.[2]. basker m j, gwynn m n, white a r. comparative activities of ampicillin, epicillin and amoxycillin in vitro and in vivo. chemotherapy, 1979, 25(3): 170-180.

Contact allergens

Ampicillin caused contact dermatitis in a nurse also sensitized to amoxicillin (with tolerance to oral phenoxymethylpenicillin) and in a pharmaceutical factory worker. Systemic drug reactions are common. Crossreactivity is regular with ampicillin and can occur with other penicillins.

Biochem/physiol Actions

Mode of Action: This is a ?-lactam antibiotic that inhibits bacterial cell-wall synthesis by inactivating transpeptidases on the inner surface of the bacterial cell membrane. Mode of Resistance: Administration with ?-lactamase cleaves the ?-lactam ring of Ampicillin and inactivates it. Antimicrobial Spectrum: Includes both gram-positive (similar to benzylpenicillin) and gram-negative bacteria (similar to tetracyclines and chloramphenicol.

Safety Profile

Moderately toxic by intraperitoneal route. Human systemic effects by ingestion: hypermotility, diarrhea, and other gastrointestinal changes. Questionable carcinogen. When heated to decomposition it emits very toxic fumes of NOx, Na2O, and SOx.

storage

+4°C

Properties of Ampicillin sodium

Melting point: 215 °C (dec.)(lit.)
alpha  +246~+272°
storage temp.  2-8°C
solubility  H2O: 50 mg/mL, clear, very faintly yellow
form  powder
color  white with slight yellow cast
PH pH(100g/l, 25℃):8.0~10.0
Water Solubility  Freely soluble in water. Sparingly soluble in acetone
BRN  4119211
CAS DataBase Reference 69-52-3(CAS DataBase Reference)

Safety information for Ampicillin sodium

Signal word Danger
Pictogram(s)
ghs
Health Hazard
GHS08
GHS Hazard Statements H317:Sensitisation, Skin
H334:Sensitisation, respiratory
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P272:Contaminated work clothing should not be allowed out of the workplace.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P284:Wear respiratory protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.

Computed Descriptors for Ampicillin sodium

InChIKey XCZQUQSOMVIRFX-AGYZSTNLNA-N
SMILES C([C@H]1C(S[C@]2([H])[C@H](NC(=O)[C@@H](C3C=CC=CC=3)N)C(=O)N12)(C)C)(=O)O.[NaH] |&1:1,4,6,10,r|

Related products of tetrahydrofuran

You may like

Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.