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HomeProduct name listAmpicillin sodium

Ampicillin sodium

Synonym(s):Ampicillin sodium salt;Ampicillin, Sodium Salt - CAS 69-52-3 - Calbiochem;Ampicillin, Sodium Salt, Sterile, Tissue Culture Grade - CAS 69-52-3 - Calbiochem;Ampicillin, Sodium Salt, Sterile-Filtered Aqueous Solution, Cell Culture Tested - CAS 69-52-3 - Calbiochem;Xylose Lysine Deoxycholate Agar

  • CAS NO.:69-52-3
  • Empirical Formula: C16H20N3NaO4S
  • Molecular Weight: 373.4
  • MDL number: MFCD00064313
  • EINECS: 200-708-1
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-12 15:22:20
Ampicillin sodium Structural

What is Ampicillin sodium?

Chemical properties

White or almost white powder, hygroscopic.

The Uses of Ampicillin sodium

Ampicillin sodium salt is a reagent for transformed cells expressing beta-lactamase. It acts as a structural analogue of acyl-D-alanyl-D-alanine, acylates the transpeptidase enzyme and prevents the cross-linking of the peptidoglycan of the cell wall necessary for the growth of the bacterium.

The Uses of Ampicillin sodium

Penicillin antibacterial.

The Uses of Ampicillin sodium

diuretic, anti-hypertensive

What are the applications of Application

Ampicillin sodium salt, cell culture grade is a widely used cell culture antibiotic

Definition

ChEBI: Ampicillin sodium is an organic sodium salt. It contains an ampicillin(1-).

brand name

Polycillin-N (Bristol-Myers Squibb).

General Description

Chemical structure: ?-lactam

Biological Activity

ampicillin sodium is a competitive inhibitor of the enzyme transpeptidase with ic50 value of 1.8 μg/ml [1].ampicillin is a β-lactam antibiotic that kills bacteria by inhibiting transpeptidase reactions. transpeptidase is involved in the final stages of cell wall biosynthesis and inhibition of it ultimately leads to cell lysis [1].in e. coli 146 cells treated with ether, ampicillin showed no significant inhibition on the transpeptidase reaction at concentrations below 0.5 μg/ml, but exhibited 50% inhibition at the concentration of 1.8 μg/ml. in e. coli 146 cells, the minimal inhibitory concentration (mic) of ampicillin was 3.1 μg/ml [1]. in e. coli and s. typhi, ampicillin and epicillin at concentrations close to mic values killed bacteria at slower rates than amoxycillin [2].in experimental mouse infections, oral or subcutaneous treatment of ampicillin at the dose of 0.2 ml/20 g was significantly more effective than epicillin and amoxycillin against the majority of infections [2].[1]. moore b a, jevons s, brammer k w. inhibition of transpeptidase activity in escherichia coli by thienamycin. antimicrobial agents and chemotherapy, 1979, 15(6): 831-833.[2]. basker m j, gwynn m n, white a r. comparative activities of ampicillin, epicillin and amoxycillin in vitro and in vivo. chemotherapy, 1979, 25(3): 170-180.

Contact allergens

Ampicillin caused contact dermatitis in a nurse also sensitized to amoxicillin (with tolerance to oral phenoxymethylpenicillin) and in a pharmaceutical factory worker. Systemic drug reactions are common. Crossreactivity is regular with ampicillin and can occur with other penicillins.

Biochem/physiol Actions

Mode of Action: This is a ?-lactam antibiotic that inhibits bacterial cell-wall synthesis by inactivating transpeptidases on the inner surface of the bacterial cell membrane. Mode of Resistance: Administration with ?-lactamase cleaves the ?-lactam ring of Ampicillin and inactivates it. Antimicrobial Spectrum: Includes both gram-positive (similar to benzylpenicillin) and gram-negative bacteria (similar to tetracyclines and chloramphenicol.

Safety Profile

Moderately toxic by intraperitoneal route. Human systemic effects by ingestion: hypermotility, diarrhea, and other gastrointestinal changes. Questionable carcinogen. When heated to decomposition it emits very toxic fumes of NOx, Na2O, and SOx.

storage

+4°C

Properties of Ampicillin sodium

Melting point: 215 °C (dec.)(lit.)
alpha  +246~+272°
storage temp.  2-8°C
solubility  H2O: 50 mg/mL, clear, very faintly yellow
form  powder
color  white with slight yellow cast
PH pH(100g/l, 25℃):8.0~10.0
Water Solubility  Freely soluble in water. Sparingly soluble in acetone
BRN  4119211
CAS DataBase Reference 69-52-3(CAS DataBase Reference)

Safety information for Ampicillin sodium

Signal word Danger
Pictogram(s)
ghs
Health Hazard
GHS08
GHS Hazard Statements H317:Sensitisation, Skin
H334:Sensitisation, respiratory
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P272:Contaminated work clothing should not be allowed out of the workplace.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P284:Wear respiratory protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.

Computed Descriptors for Ampicillin sodium

InChIKey XCZQUQSOMVIRFX-AGYZSTNLNA-N
SMILES C([C@H]1C(S[C@]2([H])[C@H](NC(=O)[C@@H](C3C=CC=CC=3)N)C(=O)N12)(C)C)(=O)O.[NaH] |&1:1,4,6,10,r|

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