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HomeProduct name listamphotalide

amphotalide

  • CAS NO.:1673-06-9
  • Empirical Formula: C19H20N2O3
  • Molecular Weight: 324.378
  • MDL number: MFCD00866729
  • EINECS: 2168099
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-28 23:16:16
amphotalide Structural

What is amphotalide?

Originator

Amphotalide,ZYF Pharm Chemical

Definition

ChEBI: Amphotalide is a member of phthalimides.

Manufacturing Process

A mixture of 5-phthalimidopentyl bromide (Drake and Garman, J.Amer. Chem. Sec, 1949, 71, 2426) (296.0 g) and potassium p-nitrophenoxide (177.0 g) in ethanol (1.5 L) was stirred mechanically, boiled under reflux for 20 h, concentrated to half its volume, cooled and filtered. The product was washed with water, dried and crystallised from acetone, giving 1-p-nitrophenoxy-5- phthalimidopentane, melting point 123°-124°C.
The foregoing 1-p-nitrophenoxy-5-phthalimidopentane (100.0 g) in ethanol (1 L) was reduced by hydrogen over 2% of platinum oxide at 74°C/73 lb. per sq. in. The filtered solution on cooling gave L-p-aminophenoxy-5-phthalimidopentane, melting point 111°-112° C (recrystallisation from ethanol).

Therapeutic Function

Antischistosomal

Properties of amphotalide

Melting point: 113-114°

Safety information for amphotalide

Computed Descriptors for amphotalide

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