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HomeProduct name listAMINOPURVALANOL A

AMINOPURVALANOL A

Synonym(s):(2R)-2-((6-((3-Amino-5-chlorophenyl)amino)-9-(1-methylethyl)-9H-purin-2-yl)amino)-3-methyl-1-butanol, NG-97;Aminopurvalanol A - CAS 220792-57-4 - Calbiochem

AMINOPURVALANOL A Structural

What is AMINOPURVALANOL A?

The Uses of AMINOPURVALANOL A

Aminopurvalanol A is a reversible and ATP-competitive inhibitor of Cdks.

What are the applications of Application

Aminopurvalanol A is a reversible and ATP-competitive inhibitor of Cdks

Definition

ChEBI: Aminopurvalanol is a purvalanol and a member of monochlorobenzenes. It has a role as a protein kinase inhibitor.

Biological Activity

Cell-permeable cyclin-dependent kinase inhibitor. IC 50 values are 0.033, 0.033, 0.028 and 0.020 μ M for cdk1/cyclin B, cdk2/cyclin A, cdk2/cyclin E, and cdk5/p35 respectively. Inhibits ERK1 (IC 50 = 12.0 μ M) and ERK2 (IC 50 = 3.1 μ M) and is 3000-fold selective over a range of other protein kinases (IC 50 > 100 μ M). Arrests cell cycle at G 2 /M boundary (IC 50 = 1.25 μ M), and induces apoptosis at concentrations > 10 μ M.

Enzyme inhibitor

This cell-permeable purvalanol derivative (FW = 403.92 g/mol), also named (2R)-2-[[6-[(3-Amino-5-chlorophenyl)amino]-9-(1-methylethyl)- 9H-purin-2-yl]amino]-3-methyl-1-butanol, targets cdk1/cyclin B (IC50 = 0.033 μM), cdk2/cyclin A (IC50 = 0.033 μM), cdk2/cyclin E (IC50 = 0.028 μM), and cdk5/p35 (IC50 = 0.020 μM). It also inhibits ERK1 (IC50 = 12 μM) and ERK2 (IC50 = 3.1 μM), with 3000-times greater selectivity versus a range of other protein kinases (IC50 > 100 μM). Aminopurvalanol A arrests cell cycle at G2/M boundary (IC50 = 1.25 μM), and induces apoptosis at concentrations > 10 μM.

storage

Store at +4°C

Properties of AMINOPURVALANOL A

Boiling point: 639.0±65.0 °C(Predicted)
Density  1.40±0.1 g/cm3(Predicted)
storage temp.  Store at +4°C
solubility  Soluble to 100 mM in DMSO
pka 14.51±0.10(Predicted)
form  White to brownish solid.
color  Off-white to light yellow

Safety information for AMINOPURVALANOL A

Computed Descriptors for AMINOPURVALANOL A

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