OLOMOUCINE II
Synonym(s):6-(2-Hydroxybenzylamino)-2-((1R)-(hydroxymethyl)propyl)amino)-9-isopropylpurine;Olomoucine II - CAS 500735-47-7 - Calbiochem
- CAS NO.：500735-47-7
- Empirical Formula: C19H26N6O2
- Molecular Weight: 370.45
- MDL number: MFCD06411574
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-07-14 17:34:45
What is OLOMOUCINE II?
What are the applications of Application
Olomoucine II is a selective inhibitor of CDK1/cyclin B and a potent cytotoxin in tumor cell lines
Definition
ChEBI: 2-[[[2-(1-hydroxybutan-2-ylamino)-9-propan-2-yl-6-purinyl]amino]methyl]phenol is a thiopurine.
General Description
A cell-permeable 2,6,9-trisubstituted purine analog that acts as a potent, reversible, and ATP-competitive inhibitor of Cdk1/B with an IC50 of 20 nM and displays increased potency over purvalanol A (Cat. No. 540500; IC50 = 50 nM), Roscovitine (Cat. No. 557360; IC50 = 450 nM), Bohemine (Cat. No. 203600; IC50 = 1.1 μM) and Olomoucine (Cat. No. 495620; IC50 = 7.0 μM). Further, exerts greater in vitro cytotoxicity in various cancer cell lines (IC50 = 3.0 μM, 5.3 μM, 6.3 μM, 6.3 μM and 11.1 μM for CEM, MCF7, HOS, G631 and K562, respectively).
Biochem/physiol Actions
Cell permeable: yes
Properties of OLOMOUCINE II
| Boiling point: | 618.5±65.0 °C(Predicted) |
| Density | 1.32 |
| storage temp. | −20°C |
| solubility | chloroform: 50 mg/mL, soluble |
| form | powder |
| pka | 9.83±0.30(Predicted) |
Safety information for OLOMOUCINE II
Computed Descriptors for OLOMOUCINE II
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