Amino-PEG5-t-butyl ester
Synonym(s):tert-Butyl-1-amino-3,6,9,12,15-pentaoxaoctadecan-18-oate;H2N-PEG5-CH2CH2COOtBu
- CAS NO.:1446282-18-3
- Empirical Formula: C17H35NO7
- Molecular Weight: 365.46
- MDL number: MFCD25424125
- Update Date: 2024-03-22 17:12:53
What is Amino-PEG5-t-butyl ester?
Description
Amino-PEG5-t-butyl ester is a PEG molecule consisting of an amino group and a t-butyl protected carboxyl group. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The t-butyl protected carboxyl group can be deprotected under acidic conditions.The hydrophilic PEG spacer increases solubility in aqueous media.
The Uses of Amino-PEG5-t-butyl ester
This heterobifunctional, PEGylated crosslinker features an amino group at one end and t-butyl-protected carboxyl group at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Amino-PEG5-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC? molecules) for targeted protein degradation.
Properties of Amino-PEG5-t-butyl ester
Boiling point: | 439.1±40.0 °C(Predicted) |
Density | 1.049±0.06 g/cm3(Predicted) |
storage temp. | -20°C |
solubility | Soluble in Water, DMSO, DCM, DMF |
pka | 8.74±0.10(Predicted) |
form | viscous liquid |
color | Light yellowish |
Safety information for Amino-PEG5-t-butyl ester
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for Amino-PEG5-t-butyl ester
New Products
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