AMINO ACID HYDROXAMATES DL-SERINE HYDROXAMATE
Synonym(s):SHX
- CAS NO.:55779-32-3
- Empirical Formula: C3H8N2O3
- Molecular Weight: 120.11
- MDL number: MFCD00055712
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:03
What is AMINO ACID HYDROXAMATES DL-SERINE HYDROXAMATE?
The Uses of AMINO ACID HYDROXAMATES DL-SERINE HYDROXAMATE
Serine has been used as an inhibitor of seryl-tRNA synthetase. DL-Serine hydroxamate is used to induce metabolic synthesis of guanosine 3′-diphosphate 5′-diphosphate (ppGpp) in E. coli by amino acid starvation. It is also used to synchronize cell cycle in E. coli cultures by inhibition of tRNA charging.
Definition
ChEBI: Serine hydroxamate is a hydroxamic acid obtained by formal condensation of the carboxy group of serine with the amino group of hydroxylamine. It has a role as an EC 6.1.1.11 (serine--tRNA ligase) inhibitor. It is a hydroxamic acid and a serine derivative.
Biochem/physiol Actions
Serine is involved in the one-carbon unit metabolism. It is associated with the biosynthesis of cysteine, ceramide, phosphatidylserine, purine and pyrimidine. In bacteria, it participates in tryptophan synthesis. Gluconeogenesis, one of the important biochemical processes, involves serine, particularly in ruminants. Protein phosphorylation is one such event that utilizes serine. Glycine, a metabolic product of serine, serves as an antioxidant and a neurotransmitter. D-serine is known to activate the N-methyl-D-aspartate (NMDA) receptors of the brain. Serine hydroxamate, a structural analogue of serine prevents seryl-tRNA (transfer ribonucleic acid) charging and thereby decreases phospholipid and nucleic acid synthesis in Escherichia coli.
Properties of AMINO ACID HYDROXAMATES DL-SERINE HYDROXAMATE
storage temp. | -20°C |
form | Solid |
color | White to off-white |
Safety information for AMINO ACID HYDROXAMATES DL-SERINE HYDROXAMATE
Computed Descriptors for AMINO ACID HYDROXAMATES DL-SERINE HYDROXAMATE
New Products
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