ALPHA-BUNGAROTOXIN
Synonym(s):α-Bungarotoxin, Bungarus multicinctus - CAS 11032-79-4 - Calbiochem
- CAS NO.：11032-79-4
- Empirical Formula: C50H70O14
- Molecular Weight: 895.0824
- MDL number: MFCD01779815
- EINECS: 234-266-6
- Update Date: 2023-06-30 15:45:59
What is ALPHA-BUNGAROTOXIN?
Chemical properties
Single polypeptide weight; molecular weight of 8000.
What are the applications of Application
α-Bungarotoxin is an α-neurotoxin which competitively and irreversibly binds and blocks nAChR
Definition
A protein that binds specifically to acetylcholine receptors.
General Description
Blocks neuromuscular transmission by irreversible binding to motor end-plate acetylcholine receptor (Kd = 1 pM to 1 nM) but does not depress acetylcholine release from motor nerve endings. Blocks nicotine-induced increase of intracellular Ca2+ in PC12 cells (IC50 = 310 nM), and prevents opening of nicotinic receptor-associated ion channels. Reconstitution experiments in Xenopus oocytes have shown the effects of α-bungarotoxin on neuronal nAChR to be highly specific for the α7-subtype (IC50 = 1.6 nM), but not for the α3β4-subtype (IC50 >3 μM).
Hazard
Nuerotoxic.
Biochem/physiol Actions
Product does not compete with ATP.
storage
-20°C (desiccate)
Properties of ALPHA-BUNGAROTOXIN
| storage temp. | −20°C |
| solubility | Soluble in sterile water |
| form | solid |
| color | white |
| Water Solubility | Soluble in water |
| CAS DataBase Reference | 11032-79-4 |
Safety information for ALPHA-BUNGAROTOXIN
Computed Descriptors for ALPHA-BUNGAROTOXIN
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