Aloin

Synonym(s):1,8-Dihydroxy-10-(β-D-glucopyranosyl)-3-(hydroxymethyl)-9(10H)-anthracenone;10-β-D-Glucopyranosyl-1,8-dihydroxy-3-(hydroxymethyl)-9(10H)-anthracenone;Aloin A;Barbaloin

CAS NO.：1415-73-2
Empirical Formula: C21H22O9
Molecular Weight: 418.39
MDL number: MFCD00151160
EINECS: 215-808-0
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-05 19:05:58

What is Aloin?

Chemical properties

lemon yellow crystalline powder

The Uses of Aloin

Aloin is a naturally occurring substance found in various Aloe plant species. Aloin was originally used as a laxative in the treatment of constipation. Recent studies have investigated Aloin as an ant ineoplastic agent that enhances melanogenesis and transglutaminase activity.

The Uses of Aloin

Aloe exudant, used as a stimulant-laxative

What are the applications of Application

Aloin is a natural anthracycline isolated from Aloe

Definition

ChEBI: A C-glycosyl compound that is beta-D-glucopyranose in which the anomeric hydroxy group is replaced by a 4,5-dihydroxy-2-(hydroxymethyl)-10-oxo-9,10-dihydroanthracen-9-yl moiety (the 9S d astereoisomer).

Safety Profile

Poison by subcutaneous andintravenous routes. Moderately toxic by ingestion. Whenheated to decomposition it emits acrid smoke and fumes.A carthartic and purgative.

Purification Methods

Aloin forms the monohydrate as lemon yellow crystals on crystallisation from H2O (450g/1.5L) which has a lower m ~70-80o than the anhydrous substance. [Cahn & Simonsen J Chem Soc 2573 1932, Hay & Haynes J Chem Soc 3141 1956.]

Properties of Aloin

Melting point:	148°C
Boiling point:	456.17°C (rough estimate)
Density	1.3028 (rough estimate)
refractive index	1.6230 (estimate)
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
solubility	pyridine: 50 mg/mL, clear, dark red
form	neat
pka	7.12±0.40(Predicted)
form	Solid
color	Yellow needles from EtOH
BRN	6077558
Stability:	Stable, but light sensitive. Incompatible with bases, strong oxidizing agents. Combustible.