Aloin
Synonym(s):1,8-Dihydroxy-10-(β-D -glucopyranosyl)-3-(hydroxymethyl)-9(10H)-anthracenone;10-β-D -Glucopyranosyl-1,8-dihydroxy-3-(hydroxymethyl)-9(10H)-anthracenone;Aloin A;Barbaloin
- CAS NO.:1415-73-2
- Empirical Formula: C21H22O9
- Molecular Weight: 418.39
- MDL number: MFCD00151160
- EINECS: 215-808-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-20 11:41:24
What is Aloin?
Chemical properties
lemon yellow crystalline powder
The Uses of Aloin
Aloin is a naturally occurring substance found in various Aloe plant species. Aloin was originally used as a laxative in the treatment of constipation. Recent studies have investigated Aloin as an ant ineoplastic agent that enhances melanogenesis and transglutaminase activity.
The Uses of Aloin
Aloe exudant, used as a stimulant-laxative
What are the applications of Application
Aloin is a natural anthracycline isolated from Aloe
Definition
ChEBI: A C-glycosyl compound that is beta-D-glucopyranose in which the anomeric hydroxy group is replaced by a 4,5-dihydroxy-2-(hydroxymethyl)-10-oxo-9,10-dihydroanthracen-9-yl moiety (the 9S d astereoisomer).
Safety Profile
Poison by subcutaneous andintravenous routes. Moderately toxic by ingestion. Whenheated to decomposition it emits acrid smoke and fumes.A carthartic and purgative.
Purification Methods
Aloin forms the monohydrate as lemon yellow crystals on crystallisation from H2O (450g/1.5L) which has a lower m ~70-80o than the anhydrous substance. [Cahn & Simonsen J Chem Soc 2573 1932, Hay & Haynes J Chem Soc 3141 1956.]
Properties of Aloin
Melting point: | 148°C |
Boiling point: | 456.17°C (rough estimate) |
Density | 1.3028 (rough estimate) |
refractive index | 1.6230 (estimate) |
storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
solubility | pyridine: 50 mg/mL, clear, dark red |
form | neat |
pka | 7.12±0.40(Predicted) |
form | Solid |
color | Yellow needles from EtOH |
BRN | 6077558 |
Stability: | Stable, but light sensitive. Incompatible with bases, strong oxidizing agents. Combustible. |
Safety information for Aloin
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral |
Computed Descriptors for Aloin
InChIKey | AFHJQYHRLPMKHU-WEZNYRQKSA-N |
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