Alibendol
- CAS NO.:26750-81-2
- Empirical Formula: C13H17NO4
- Molecular Weight: 251.28
- MDL number: MFCD00865165
- EINECS: 247-960-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-05-21 17:03:17
What is Alibendol?
Chemical properties
White Solid
Originator
Cebera ,Bouchara ,France ,1981
The Uses of Alibendol
Alibendol is an antispasmodic,choleretic, and cholekinetic.
The Uses of Alibendol
An amide analog of Eugenol, and is used therapeutically as an antispasmodic.
Definition
ChEBI: Alibendol is a member of salicylamides.
Manufacturing Process
36 g of ethyl ester of 2-hydroxy-3-methoxy-5-allyl-benzoic acid [obtained by the process described by Pearl, et al., J. Amer. Chem. Soc., Vol. 71, 1067- 1068 (1949)] and 61 g of ethanolamine were admixed and left to stand for 1 hour at ambient temperature after which it was heated for 1 hour at 120°C. The mixture was extracted with chloroform and the organic phases were washed with half diluted hydrochloric acid, then with water, and the chloroform evaporated off. The residue, after recrystallization from benzene, was a 78% yield of 2-hydroxy-3-methoxy-5-allyl-N-(β-hydroxyethyl)- benzamide having a melting point of 95°C. The product appeared in the form of colorless crystals which were insoluble in water and soluble in dilute sodium hydroxide.
Therapeutic Function
Choleretic, Spasmolytic
Properties of Alibendol
Melting point: | 97-99°C |
Boiling point: | 402.4±45.0 °C(Predicted) |
Density | 1.192±0.06 g/cm3(Predicted) |
storage temp. | Sealed in dry,Room Temperature |
solubility | DMSO, Methanol |
form | Solid |
pka | 8.59±0.48(Predicted) |
color | White |
λmax | 316nm(EtOH)(lit.) |
Merck | 14,244 |
CAS DataBase Reference | 26750-81-2(CAS DataBase Reference) |
Safety information for Alibendol
Computed Descriptors for Alibendol
New Products
(S)-3-Aminobutanenitrile hydrochloride 4-Methylphenylacetic acid N-Boc-D-alaninol N-BOC-D/L-ALANINOL Tert-butyl bis(2-chloroethyl)carbamate 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin- 2(1H)-one Furan-2,5-Dicarboxylic Acid Tropic acid 1-Bromo-3,5-Di-Tert-Butylbenzene S-2-CHLORO PROPIONIC ACID ETHYL ISOCYANOACETATE 2-Bromo-1,3-Bis(Dimethylamino)Trimethinium Hexafluorophosphate 4-IODO BENZOIC ACID 3-NITRO-2-METHYL ANILINE 1-(2,4-DICHLOROPHENYL) ETHANAMINE (2-Hydroxyphenyl)acetonitrile 4-Bromopyrazole 2-(Cyanocyclohexyl)acetic acid 4-methoxy-3,5-dinitropyridine 1-(4-(aminomethyl)benzyl)urea hydrochloride 2-aminopropyl benzoate hydrochloride diethyl 2-(2-((tertbutoxycarbonyl)amino) ethyl)malonate tert-butyl 4- (ureidomethyl)benzylcarbamate Ethyl-2-chloro((4-methoxyphenyl)hydrazono)acetateRelated products of tetrahydrofuran
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