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HomeProduct name listALFENTANIL HYDROCHLORIDE

ALFENTANIL HYDROCHLORIDE

  • CAS NO.:69049-06-5
  • Empirical Formula: C21H33ClN6O3
  • Molecular Weight: 452.98
  • MDL number: MFCD00941457
  • EINECS: 273-846-3
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-06-08 09:02:38
ALFENTANIL HYDROCHLORIDE Structural

What is ALFENTANIL HYDROCHLORIDE?

Description

Alfentanil is a narcotic analgesic with a more rapid onset and shorter duration of action than its structural relative fentanyl. The primary utility of alfentanil is in surgical analgesia/anesthesia, especially for cardiac compromised patients and in procedures of short duration.

Description

Alfentanil (hydrochloride) (Item No. 19292) is an analytical reference standard characterized as an opioid. Alfentanil is regulated as a Schedule II compound in the United States. This product is intended for research and forensic applications.

Chemical properties

Tan Solid

Originator

Jansseu (Belgium)

The Uses of ALFENTANIL HYDROCHLORIDE

An opioid analgesic receptor agonist for pain treatment. Tetrazole derivative of Fentanyl. Analgesic (narcotic). Controlled substance (opiate)

Manufacturing Process

A mixture of 22 parts of 1-ethyl-1,4-dihydro-5H-tetrazol-5-one, 45 parts of 1- bromo-2-chloroethane, 26 parts of sodium carbonate, 0.3 part of potassium iodide and 240 parts of 4-methyl-2-pentanone is stirred and refluxed overnight with water-separator. The reaction mixture is cooled, water is added and the layers are separated. The aqueous phase is extracted three times with dichloromethane. The combined organic phases are dried, filtered and evaporated. The residue is purified by column-chromatography over silica gel using trichloromethane as eluent. The pure fractions are collected and the eluent is evaporated, yielding 28.4 parts (80%) of 1-(2-chloroethyl)-4-ethyl- 1,4-dihydro-5H-tetrazol-5-one as a residue.
A mixture of 1.8 parts of 1-(2-chloroethyl)-4-ethyl-1,4-dihydro-5H-tetrazol-5- one, 3.45 parts of N-[4-(methoxymethyl)-4-piperidinyl]-Nphenylpropanamide, 5 parts of sodium carbonate, 0.2 part of potassium iodide and 240 parts of 4-methyl-2-pentanone is stirred and refluxed overnight with water-separator. The reaction mixture is poured onto water and the layers are separated. The organic phase is dried, filtered and evaporated. The residue is purified by column-chromatography over silicagel using a mixture of trichloromethane and methanol (97:3 by volume) as eluent. The pure fractions are collected and the eluent is evaporated. The residue is converted into the hydrochloride salt in 2-propanone. The salt is filtered off and crystallized from 2-propanone, yielding 1.5 parts (33.3%) of N-[1-[2-(4-ethyl- 4,5-dihydro-5-oxo-1H-tetrazol-1-yl]-4-(methoxymethyl)-4-piperidinyl]-Nphenylpropanamide monohydrochloride monohydrate; melting point 140.8°C.

brand name

Alfenta (Akorn);RAPIFEN.

Therapeutic Function

Narcotic analgesic

Properties of ALFENTANIL HYDROCHLORIDE

Melting point: 92-94?C
Flash point: 9℃
storage temp.  Controlled Substance, -20°C Freezer
solubility  Freely soluble in water, in ethanol (96 per cent) and in methanol.
form  A crystalline solid
Stability: Hygroscopic

Safety information for ALFENTANIL HYDROCHLORIDE

Signal word Danger
Pictogram(s)
ghs
Flame
Flammables
GHS02
ghs
Skull and Crossbones
Acute Toxicity
GHS06
ghs
Health Hazard
GHS08
GHS Hazard Statements H225:Flammable liquids
H370:Specific target organ toxicity, single exposure
Precautionary Statement Codes P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P370+P378:In case of fire: Use … for extinction.
P403+P235:Store in a well-ventilated place. Keep cool.

Computed Descriptors for ALFENTANIL HYDROCHLORIDE

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