ailanthone

Synonym(s):Δ13-Dehydrochaparrinone;(1β,11β,12α)-11,20-Epoxy-1,11,12-trihydroxypicrasa-3,13(21)-diene-2,16-dione;13,21-Didehydrochaparrinone

CAS NO.：981-15-7
Empirical Formula: C20H24O7
Molecular Weight: 376.4
MDL number: MFCD01729487
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-09 19:38:33

What is ailanthone?

Description

Ailanthone is a quassinoid that has been found in Ailanthus and has diverse biological activities. It is active against the P. falciparum strains HB-3 and Dd-2 in vitro (IC₅₀s = 0.003 and 0.037 μg/ml, respectively). Ailanthone is phytotoxic, inhibiting radish seed germination by 88% when used at a concentration of 1 mM. It inhibits dihydrotestosterone-induced androgen receptor transcriptional activity (IC₅₀ = 69 nM in a reporter assay), as well as the growth and colony formation of LNCaP and 22RV1 androgen receptor-expressing cells, but not androgen receptor-negative PC3 and DU145 cells, when used at a concentration of 0.1 μM. Ailanthone (2 mg/kg) reduces tumor volume in 22Rv1, LNCaP, and VCaP castration-resistant prostate cancer (CRPC) mouse xenograft models.

The Uses of ailanthone

Ailanthone has potent antineoplastic activity against anti-hepatocellular carcinoma (HCC) and has been shown to inhibit Huh7 cancer cell growth through cell cycle arrest and apoptosis in vitro and in vivo.

Definition

ChEBI: Ailanthone is a triterpenoid.

Properties of ailanthone

Melting point:	235-237 °C
Boiling point:	641.0±55.0 °C(Predicted)
Density	1.47
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	DMSO:100.0(Max Conc. mg/mL);265.67(Max Conc. mM)
form	A crystalline solid
pka	11.85±0.70(Predicted)
color	White to off-white