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Home Product name listAEA-P

AEA-P

CAS NO.：183323-26-4
Empirical Formula: C22H38NO5P
Molecular Weight: 427.51
MDL number: MFCD08062225
SAFETY DATA SHEET (SDS)
Update Date: 2023-06-08 09:03:09

AEA-P Structural

What is AEA-P?

Description

Arachidonoyl ethanolamide (AEA; ) was the first endogenous cannabinoid (CB) to be isolated and characterized as an agonist acting on the same receptors (CB₁ and CB₂) as Δ⁹-THC . Since that time, a number of related endocannabinoids have been isolated, most notably 2-arachidonoyl glycerol (2-AG; ). The phosphate ester of AEA, AEA-P, has been tested as a water soluble prodrug version of AEA in the treatment of C₆ glioma cells in vivo. Here it acts with essentially the same potency as AEA. However, when tested for inhibition of AEA binding to isolated rat brain CB₁ receptors, AEA-P is about 5-fold less potent as an agonist with a K_i of about 200 nM. The phosphate esters of AEA and its analogs are also structural variants of lysophosphatidic acid (LPA). However, the effects of AEA-P on the various LPA receptors have not been tested.

Definition

ChEBI: Phospho-anandamide is a phosphoethanolamine and a N-acylethanolamine phosphate.

Properties of AEA-P

Density	1.075±0.06 g/cm3(Predicted)
solubility	DMF: 20 mg/ml; DMSO: 20 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 5 mg/ml
pka	1.86±0.10(Predicted)

Safety information for AEA-P

Computed Descriptors for AEA-P

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Related products of tetrahydrofuran

ANANDAMIDE

AEA-P

N-(2-PHOSPHATE-1R-METHYLETHYL)-5Z,8Z,11Z,14Z-EICOSATETRAENAMIDE

N-(2-PHOSPHATE-1R-METHYLETHYL)-5Z,8Z,11Z,14Z-EICOSATETRAENAMIDE

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