Adrenosterone
Synonym(s):11-Ketoandrostenedione;4-Androstene-3,11,17-trione;Androst-4-ene-3,11,17-trione;Reichstein’s substance G
- CAS NO.:382-45-6
- Empirical Formula: C19H24O3
- Molecular Weight: 300.39
- MDL number: MFCD00003606
- EINECS: 206-843-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 14:09:54
What is Adrenosterone?
Chemical properties
Off-White to Pale Yellow Solid
The Uses of Adrenosterone
Androgenic activity;Androgenic steroid
Definition
ChEBI: Adrenosterone is a 3-oxo Delta(4)-steroid that is androst-4-ene carrying three oxo-substituents at positions 3, 11 and 17. It has a role as an androgen, a human urinary metabolite, a marine metabolite and an EC 1.1.1.146 (11beta-hydroxysteroid dehydrogenase) inhibitor. It is a 3-oxo-Delta(4) steroid, a 17-oxo steroid, an androstanoid and an 11-oxo steroid. It derives from a hydride of an androstane.
Benefits
Adrenosterone is sold as a dietary supplement since 2007 as a fat loss and muscle gaining supplement. It is thought to be a competitive selective 11βHSD1 inhibitor, which is responsible for activation of cortisol from cortisone. Thus preventing muscle breakdown, and contributing to a majority of its effects.
Purification Methods
Dissolve adrenosterone i n Me2CO, decolorise it with charcoal, filter, add H2O, Me2CO evaporate and the solid is recrystallised from aqueous EtOH. Also recrystallise it from Et2O or Et2O/pentane and dry it at 110o/0.1mm for 2hours. It can be sublimed under high vacuum. [Reichstein Helv Chim Acta 20 953, 979 1937, Mason et al. J Biol Chem 116 267 1936, Beilstein 7 III 4601.]
Properties of Adrenosterone
Melting point: | 219-222 °C(lit.) |
Boiling point: | 381.62°C (rough estimate) |
alpha | 300 º (c=1 in chloroform) |
Density | 1.1381 (rough estimate) |
refractive index | 290 ° (C=0.2, EtOH) |
storage temp. | Sealed in dry,Room Temperature |
solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
form | Solid |
color | White to Off-White |
optical activity | [α]20/D +300°, c = 1 in chloroform |
Water Solubility | 98.49mg/L(23.5 ºC) |
Merck | 14,176 |
CAS DataBase Reference | 382-45-6(CAS DataBase Reference) |
NIST Chemistry Reference | Androst-4-ene-3,11,17-trione(382-45-6) |
Safety information for Adrenosterone
Computed Descriptors for Adrenosterone
InChIKey | RZRPTBIGEANTGU-IRIMSJTPSA-N |
New Products
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