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HomeProduct name listADRENOMEDULLIN (HUMAN)

ADRENOMEDULLIN (HUMAN)

  • CAS NO.:148498-78-6
  • Empirical Formula: C264H406N80O77S3
  • Molecular Weight: 6028.73324
  • MDL number: MFCD00211549
  • Update Date: 2024-03-27 11:49:37
ADRENOMEDULLIN (HUMAN) Structural

What is ADRENOMEDULLIN (HUMAN)?

The Uses of ADRENOMEDULLIN (HUMAN)

Peptide elicits potent hypotensive effect, comparable to calcitonin gene-related peptide. Plays a key role in regulating endometrial angiogenesis.

General Description

Adrenomedullin (ADM) human comprises of 52 amino acids and has amine group in the C-terminal tyrosine residue. It also has a N-terminal ring structure and belongs to calcitonin peptide family. ADM has vasodilatory function and is mapped to human chromosome 11p15.4. Adrenomedullin is highly expressed in endothelial cells. Adrenomedullin controls a majority of cellular processes using cyclic adenosine monophosphate (cAMP) as a messenger. It interacts with calcitonin receptor-like receptor (CRLR) and receptor activity modifying protein 2 (RAMP2). ADM contributes to invasion activity in brain tumor cell lines. ADM signalling plays a key role in tumor progression, especially in acute myeloid leukemia.

Biochem/physiol Actions

Peptide elicits potent hypotensive effect, comparable to calcitonin gene-related peptide. Plays a key role in regulating endometrial angiogenesis.

Properties of ADRENOMEDULLIN (HUMAN)

storage temp.  -20°C
solubility  Soluble at 1mg/ml in 1% acetic acid
form  powder

Safety information for ADRENOMEDULLIN (HUMAN)

Computed Descriptors for ADRENOMEDULLIN (HUMAN)

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