ACONINE
- CAS NO.:509-20-6
- Empirical Formula: C25H41NO9
- Molecular Weight: 499.6
- MDL number: MFCD01673464
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-08-24 17:20:48
What is ACONINE?
Description
Aconine is an alkaloid originally isolated from Aconitum species and active metabolite of aconitine. It inhibits osteoclast differentiation of RANKL-stimulated RAW 264.7 cells and bone resorption in a pit formation assay in a concentration-dependent manner. Aconine also inhibits RANKL-induced activation of NF-κB and NFATc1 in RAW 264.7 cells. In vivo, aconine is toxic to mice when administered intravenously at a dose of 120 mg/kg. It induces flaccid paralysis and toxicity in rats with toxic dose (TD50) and LD50 values of 1.5 and 1.7 μmol per animal, respectively.
The Uses of ACONINE
Aconine is a derivative of Aconitine (A189875), a neurotoxin which activates tetrodotoxin-sensitive Na+ channels, inducing presynaptic depolarization, thus blocking the nerve action potential which, in turn, blocks the release of neurotransmitters and decreases the end plate potential at the neuromuscular junction.
Definition
ChEBI: Aconine is a diterpene alkaloid with formula C25H41NO9 that is isolated from several Aconitum species. It has a role as a plant metabolite, a human urinary metabolite, a NF-kappaB inhibitor and a xenobiotic. It is a bridged compound, a diterpene alkaloid, an organic heteropolycyclic compound, a polyether, a tertiary amino compound, a pentol, a secondary alcohol and a tertiary alcohol. It derives from a hydride of an aconitane.
Properties of ACONINE
Melting point: | 129-131℃ |
Boiling point: | 590.79°C (rough estimate) |
alpha | D +23° |
Density | 1.42 |
refractive index | 1.6000 (estimate) |
storage temp. | -20°C Freezer |
solubility | Chloroform (Slightly), DMSO (Slightly) |
form | Solid |
pka | 9.52(at 25℃) |
color | Off-White to Pale Yellow |
Safety information for ACONINE
Computed Descriptors for ACONINE
Related products of tetrahydrofuran
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