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HomeProduct name listACONINE

ACONINE

  • CAS NO.:509-20-6
  • Empirical Formula: C25H41NO9
  • Molecular Weight: 499.6
  • MDL number: MFCD01673464
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-08-24 17:20:48
ACONINE Structural

What is ACONINE?

Description

Aconine is an alkaloid originally isolated from Aconitum species and active metabolite of aconitine. It inhibits osteoclast differentiation of RANKL-stimulated RAW 264.7 cells and bone resorption in a pit formation assay in a concentration-dependent manner. Aconine also inhibits RANKL-induced activation of NF-κB and NFATc1 in RAW 264.7 cells. In vivo, aconine is toxic to mice when administered intravenously at a dose of 120 mg/kg. It induces flaccid paralysis and toxicity in rats with toxic dose (TD50) and LD50 values of 1.5 and 1.7 μmol per animal, respectively.

The Uses of ACONINE

Aconine is a derivative of Aconitine (A189875), a neurotoxin which activates tetrodotoxin-sensitive Na+ channels, inducing presynaptic depolarization, thus blocking the nerve action potential which, in turn, blocks the release of neurotransmitters and decreases the end plate potential at the neuromuscular junction.

Definition

ChEBI: Aconine is a diterpene alkaloid with formula C25H41NO9 that is isolated from several Aconitum species. It has a role as a plant metabolite, a human urinary metabolite, a NF-kappaB inhibitor and a xenobiotic. It is a bridged compound, a diterpene alkaloid, an organic heteropolycyclic compound, a polyether, a tertiary amino compound, a pentol, a secondary alcohol and a tertiary alcohol. It derives from a hydride of an aconitane.

Properties of ACONINE

Melting point: 129-131℃
Boiling point: 590.79°C (rough estimate)
alpha  D +23°
Density  1.42
refractive index  1.6000 (estimate)
storage temp.  -20°C Freezer
solubility  Chloroform (Slightly), DMSO (Slightly)
form  Solid
pka 9.52(at 25℃)
color  Off-White to Pale Yellow

Safety information for ACONINE

Computed Descriptors for ACONINE

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