KARAKOLINE
- CAS NO.:39089-30-0
- Empirical Formula: C22H35NO4
- Molecular Weight: 377.52
- MDL number: MFCD00274546
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:07
What is KARAKOLINE?
Description
A second atisine base found in the tubers of Aconitum karacolicum, the structure has been elucidated from chemical and spectroscopic data. Oxidation with KMn04 gives anhydroepoxykaracoline. The alkaloid furnishes a triacetyl deriva_x0002_tive which, after pyrolysis and hydrolysis, yields acetyldemethylisopyrokaracoline.
The Uses of KARAKOLINE
Karacoline is an Aconitane (A189875) derivative, which is a neurotoxin which activates tetrodotoxin-sensitive Na+ channels, inducing presynaptic depolarization, thus blocking the nerve action potential which, in turn, blocks the release of neurotransmitters and decreases the end plate potential at the neuromuscular junction.
Definition
ChEBI: An organonitrogen heterocyclic compound that is aconitane bearing hydroxy groups at the 1alpha, 8, and 14alpha positions and substituted at on the nitrogen and at positions 4 and 16beta by ethyl, methyl, a d methoxy groups, respectively.
References
Sultankhodzhaev, Yunusov, Yunusov., Khim. Prir. Soedin., 9, 199 (1973)
Properties of KARAKOLINE
Melting point: | 185-186℃ (acetone ) |
Boiling point: | 540.2±50.0 °C(Predicted) |
Density | 1.30±0.1 g/cm3 (20 ºC 760 Torr) |
storage temp. | 2-8°C |
form | Solid |
pka | 13.80±0.70(Predicted) |
color | White to off-white |
Safety information for KARAKOLINE
Computed Descriptors for KARAKOLINE
New Products
Tubulysin F Tubulysin I Tubulysin G Tubulysin E 2-(azetidin-3-ylidene)acetonitrile (hydrochloride) tetrahydro-4-methyl-2H-pyran Methyl (R)-1-Boc-4,4-difluoropyrrolidine-2-carboxylate 1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE 2,2-Difluoropropanol 4,4-DIFLUOROPIPERIDINE 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol Calcium Sodium Phosphosilicate IH Imeglimin Hydrochloride IH Fuel shell Magnesium Trisilicate Latanoprostene Bunod Lubiprostone Flame Retardant Zinc Borate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate methyl 3-fluoro-4- thiomorpholino phenylcarbamate 7-Methoxyquinoline-4-carbonitrile 7-Methoxyquinoline-4-carboxylic acidRelated products of tetrahydrofuran
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