KARAKOLINE
- CAS NO.：39089-30-0
- Empirical Formula: C22H35NO4
- Molecular Weight: 377.52
- MDL number: MFCD00274546
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33
What is KARAKOLINE?
Description
A second atisine base found in the tubers of Aconitum karacolicum, the structure has been elucidated from chemical and spectroscopic data. Oxidation with KMn04 gives anhydroepoxykaracoline. The alkaloid furnishes a triacetyl deriva_x0002_tive which, after pyrolysis and hydrolysis, yields acetyldemethylisopyrokaracoline.
The Uses of KARAKOLINE
Karacoline is an Aconitane (A189875) derivative, which is a neurotoxin which activates tetrodotoxin-sensitive Na+ channels, inducing presynaptic depolarization, thus blocking the nerve action potential which, in turn, blocks the release of neurotransmitters and decreases the end plate potential at the neuromuscular junction.
Definition
ChEBI: An organonitrogen heterocyclic compound that is aconitane bearing hydroxy groups at the 1alpha, 8, and 14alpha positions and substituted at on the nitrogen and at positions 4 and 16beta by ethyl, methyl, a d methoxy groups, respectively.
References
Sultankhodzhaev, Yunusov, Yunusov., Khim. Prir. Soedin., 9, 199 (1973)
Properties of KARAKOLINE
| Melting point: | 185-186℃ (acetone ) |
| Boiling point: | 540.2±50.0 °C(Predicted) |
| Density | 1.30±0.1 g/cm3 (20 ºC 760 Torr) |
| storage temp. | 2-8°C |
| form | Solid |
| pka | 13.80±0.70(Predicted) |
| color | White to off-white |
Safety information for KARAKOLINE
Computed Descriptors for KARAKOLINE
New Products
Tert-butyl bis(2-chloroethyl)carbamate (S)-3-Aminobutanenitrile hydrochloride N-Boc-D-alaninol N-BOC-D/L-ALANINOL 3-(2,4-Dimethoxybenzyl)dihydropyrimidine-2,4(1H,3H)-dione 7-Bromo-1H-indazole N-octanoyl benzotriazole 3,4-Dibenzyloxybenzaldehyde 4-Hydrazinobenzoic acid Electrolytic Iron Powder Fmoc-Val-Cit-PAB 1,1’-CARBONYLDIIMIDAZOLE R-2-BENZYLOXY PROPIONIC ACID 4-HYDROXY BENZYL ALCOHOL 1,1’-CARBONYLDI (1,2-4 TRIAZOLE) S-2-CHLORO PROPIONIC ACID (2-Hydroxyphenyl)acetonitrile 4-Bromopyrazole 5-BROMO-2CYANO PYRIDINE 5,6-Dimethoxyindanone 5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine 1-(4-Methylphenylsulfonyl)-1H-1,2,3-benzotriazole 1-(2-Chlorobenzyl)-4-nitro-1H-pyrazole 1-(2-Nitrophenyl)-4-phenylpiperazineRelated products of tetrahydrofuran
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