ACETYL-DL-CARNITINE HYDROCHLORIDE
Synonym(s):(±)-3-Acetoxy-4-(trimethylammonio)butyrate hydrochloride
- CAS NO.:2504-11-2
- Empirical Formula: C9H18ClNO4
- Molecular Weight: 239.7
- MDL number: MFCD00080826
- EINECS: 2197093
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-12 15:22:20
What is ACETYL-DL-CARNITINE HYDROCHLORIDE?
The Uses of ACETYL-DL-CARNITINE HYDROCHLORIDE
(±)-Acetylcarnitine Chloride is a drug absorption-enhancing agent in the gastrointestinal tract.
What are the applications of Application
(±)-Acetylcarnitine chloride is a weak cholinergic agonist
Biological Activity
(±)-acetylcarnitine chloride is an agonist for cholinergic.acetylcholine receptor (achr) is an integral membrane protein receptor for acetylcholine. there are two kinds of achrs: nicotinic acetylcholine receptors and muscarinic acetylcholine receptors.(±)-acetylcarnitine chloride is a cholinergic agonist and an intermediate in lipid metabolism [1]. in retinal ganglion cells, acetylcarnitine and acetylcholine inhibited gabaergic responses to exogenous gaba and gabaergic inhibitory postsynaptic currents [2].in dogs with coronary ligation, (-)-carnitine chloride (lcc) (300 mg/kg) and acetyl (-)-carnitine chloride (alcc) (300 mg/kg) inhibited the ventricular arrhythmia. also, lcc and alcc improved oxidative phosphorylation rate and the mitochondrial function [1]. in the mouse hot plate test, acetyl-l-carnitine (alcar) (100 mg/kg) exhibited analgesia. while, u-73122 and neomycin (the phospholipase c (plc) inhibitors) blocked the increase of the pain threshold induced by alcar. licl that impairing phosphatidylinositol synthesis antagonized the antinociception in a dose-dependent way. pma and pdbu (pkc activators) blocked the increase of the pain threshold in a dose-dependent way. these results suggested that alcar analgesia required the participation of the plc-ip3 pathway [3].
Biochem/physiol Actions
Weak cholinergic receptor agonist; intermediate in lipid metabolism.
Purification Methods
Recrystallise the chloride from isopropanol. Dry it over P2O5 under high vacuum. The S-betaine crystallises from EtOH/Et2O with m 145o(dec) and is hygroscopic; it has [] D -19.5o (c 6, H2O). [Krimberg & Wittandt Biochem Z 251 231 1932, Strack et al. Z Physiol Chem 238 191 1936, Beilstein 4 III 1630, 1632.]
Properties of ACETYL-DL-CARNITINE HYDROCHLORIDE
Melting point: | 181 - 183°C |
storage temp. | -20°C |
solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
form | Solid |
color | White to Off-White |
Water Solubility | Soluble to 100 mM in water |
Stability: | Hygroscopic |
CAS DataBase Reference | 2504-11-2(CAS DataBase Reference) |
Safety information for ACETYL-DL-CARNITINE HYDROCHLORIDE
Computed Descriptors for ACETYL-DL-CARNITINE HYDROCHLORIDE
New Products
4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Diclofenac Sodium IP/BP/EP/USP Mefenamic Acid IP/BP/EP/USP Ornidazole IP Diclofenac Potassium THOMAIND PAPER PH 2.0 TO 4.5 1 BOX BUFFER CAPSULE PH 9.2 - 10 CAP SODIUM CHLORIDE 0.1N CVS ALLOXAN MONOHYDRATE 98% PLATINUM 0.5% ON 3 MM ALUMINA PELLETS (TYPE 73) LITHIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
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