ACETONYLTRIPHENYLPHOSPHONIUM CHLORIDE
Synonym(s):2-Oxopropyl triphenylphosphonium chloride;Acetonyltriphenylphosphonium chloride
- CAS NO.:1235-21-8
- Empirical Formula: C21H20ClOP
- Molecular Weight: 354.81
- MDL number: MFCD00011813
- EINECS: 214-974-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-08 13:40:43
What is ACETONYLTRIPHENYLPHOSPHONIUM CHLORIDE?
Chemical properties
WHITE TO SLIGHTLY BEIGE FINE CRYSTALLINE POWDER
The Uses of ACETONYLTRIPHENYLPHOSPHONIUM CHLORIDE
Acetonyltriphenylphosphonium chloride is used to investigate the antimycobacterial activities of Me alkenyl quinolones. It is used as a reactant for synthesis of unsaturated esters and ketones containing multiple aromatic and heteroaromatic rings using Suzuki coupling - Wittig olefination.
The Uses of ACETONYLTRIPHENYLPHOSPHONIUM CHLORIDE
Used to investigate the antimycobacterial activities of Me alkenyl quinolones
Reactant for synthesis of:
- Unsaturated esters and ketones containing multiple aromatic and heteroaromatic rings using Suzuki coupling - Wittig olefination
- Fused oxygen and nitrogen heterocycles via regioselective cyclocondensation
Reactant for Wittig olefinations
Purification Methods
Recrystallise it from CHCl3/*C6H6/pet ether (b 60-80o) or by dissolving it in CHCl3 and pouring it into dry Et2O. max nm() 255(3,600), 262(3,700), 268(4,000) and 275(3,100). The iodide salt crystallises from H2O and has m 207-209o. [Ramirez & Dershowitz J Org Chem 22 41 1957.] Itisan IRRITANT and is hygroscopic. When shaken with a 10% aqueous solution of Na2CO3 (8hours) it gives acetylmethylene triphenyl phosphorane which is recrystallised from MeOH/H2O and after drying at 70o/0.1mm has m 205-206o. UV: nm() 268 (6600), 275 (6500) and 288 (5700), IR: max 1529 (s), 1470 (m), 1425 (s), max 1374 (m), 1105 and 978 (s) (cm-1). [Ramirez & Dershowitz J Org Chem 22 41, 44 1957, Beilstein 16 H 761, 16 II 373.]
Properties of ACETONYLTRIPHENYLPHOSPHONIUM CHLORIDE
Melting point: | 243-245 °C(lit.) |
storage temp. | Store below +30°C. |
form | solid |
color | White to Light yellow to Light orange |
Water Solubility | Soluble in hot water. |
Sensitive | Hygroscopic |
CAS DataBase Reference | 1235-21-8(CAS DataBase Reference) |
Safety information for ACETONYLTRIPHENYLPHOSPHONIUM CHLORIDE
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for ACETONYLTRIPHENYLPHOSPHONIUM CHLORIDE
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