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HomeProduct name listACETONYLTRIPHENYLPHOSPHONIUM CHLORIDE

ACETONYLTRIPHENYLPHOSPHONIUM CHLORIDE

Synonym(s):2-Oxopropyl triphenylphosphonium chloride;Acetonyltriphenylphosphonium chloride

  • CAS NO.:1235-21-8
  • Empirical Formula: C21H20ClOP
  • Molecular Weight: 354.81
  • MDL number: MFCD00011813
  • EINECS: 214-974-1
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-08-08 13:40:43
ACETONYLTRIPHENYLPHOSPHONIUM CHLORIDE Structural

What is ACETONYLTRIPHENYLPHOSPHONIUM CHLORIDE?

Chemical properties

WHITE TO SLIGHTLY BEIGE FINE CRYSTALLINE POWDER

The Uses of ACETONYLTRIPHENYLPHOSPHONIUM CHLORIDE

Acetonyltriphenylphosphonium chloride is used to investigate the antimycobacterial activities of Me alkenyl quinolones. It is used as a reactant for synthesis of unsaturated esters and ketones containing multiple aromatic and heteroaromatic rings using Suzuki coupling - Wittig olefination.

The Uses of ACETONYLTRIPHENYLPHOSPHONIUM CHLORIDE

Used to investigate the antimycobacterial activities of Me alkenyl quinolones

Reactant for synthesis of:

  • Unsaturated esters and ketones containing multiple aromatic and heteroaromatic rings using Suzuki coupling - Wittig olefination
  • Fused oxygen and nitrogen heterocycles via regioselective cyclocondensation

Reactant for Wittig olefinations

Purification Methods

Recrystallise it from CHCl3/*C6H6/pet ether (b 60-80o) or by dissolving it in CHCl3 and pouring it into dry Et2O. max nm() 255(3,600), 262(3,700), 268(4,000) and 275(3,100). The iodide salt crystallises from H2O and has m 207-209o. [Ramirez & Dershowitz J Org Chem 22 41 1957.] Itisan IRRITANT and is hygroscopic. When shaken with a 10% aqueous solution of Na2CO3 (8hours) it gives acetylmethylene triphenyl phosphorane which is recrystallised from MeOH/H2O and after drying at 70o/0.1mm has m 205-206o. UV: nm() 268 (6600), 275 (6500) and 288 (5700), IR: max 1529 (s), 1470 (m), 1425 (s), max 1374 (m), 1105 and 978 (s) (cm-1). [Ramirez & Dershowitz J Org Chem 22 41, 44 1957, Beilstein 16 H 761, 16 II 373.]

Properties of ACETONYLTRIPHENYLPHOSPHONIUM CHLORIDE

Melting point: 243-245 °C(lit.)
storage temp.  Store below +30°C.
form  solid
color  White to Light yellow to Light orange
Water Solubility  Soluble in hot water.
Sensitive  Hygroscopic
CAS DataBase Reference 1235-21-8(CAS DataBase Reference)

Safety information for ACETONYLTRIPHENYLPHOSPHONIUM CHLORIDE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405:Store locked up.

Computed Descriptors for ACETONYLTRIPHENYLPHOSPHONIUM CHLORIDE

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