a-Hydroxy Tamoxifen
- CAS NO.：97151-02-5
- Empirical Formula: C26H29NO2
- Molecular Weight: 387.52
- MDL number: MFCD02101152
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-08 09:03:09
What is a-Hydroxy Tamoxifen?
Description
Tamoxifen is a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of breast cancer. Although it is an antagonist of ER action in breast tissue, it acts as an ER agonist in bone and blood vessels and a partial ER agonist in uterine tissues. α-hydroxy Tamoxifen is a reactive metabolite of tamoxifen that is formed by the action of cytochrome P450 3A4 in human liver. It can be further converted into genotoxic DNA adducts though a mechanism involving reversible O-sulfonation of the hydroxyl moiety, which in rats has been linked with hepatocarcinoma.
Chemical properties
Pale Yellow Solid
The Uses of a-Hydroxy Tamoxifen
A metabolite of the chemotherapeutic drug tamoxifen. Exhibits a more potent estrogen agonist/antagonist activity than the parent drug. Also active as an intramembranous inhibitor of lipid peroxidation.
The Uses of a-Hydroxy Tamoxifen
A metabolite of the chemotherapeutic drug Tamoxifen (T006000). Exhibits a more potent estrogen agonist/antagonist activity than the parent drug. Also active as an intramembranous inhibitor of lipid peroxidation.
What are the applications of Application
α-Hydroxy Tamoxifen is an agonist/antagonist of estrogen
Definition
ChEBI: Alpha-Hydroxytamoxifen is a stilbenoid.
Properties of a-Hydroxy Tamoxifen
| Melting point: | 115-119°C |
| Boiling point: | 533.8±50.0 °C(Predicted) |
| Density | 1.094±0.06 g/cm3(Predicted) |
| storage temp. | Amber Vial, -20°C Freezer |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 14.13±0.20(Predicted) |
| color | Pale Yellow to Pale Beige |
Safety information for a-Hydroxy Tamoxifen
Computed Descriptors for a-Hydroxy Tamoxifen
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