Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name list8-hydroxyloxapine

8-hydroxyloxapine

8-hydroxyloxapine Structural

What is 8-hydroxyloxapine?

Description

8-hydroxy Loxapine (8-OH loxapine) is a metabolite formed when loxapine , an atypical antipsychotic, is metabolized by the cytochrome P450 isoform CYP1A2. Loxapine displays high affinity for histamine, serotonin (5-HT), dopamine, and α1-adrenergic receptors (Ki values = 7, 7.7, 9.5, 12, and 31 nM for H1, 5-HT2A, 5-HT2C, D2, and α1A-adrenergic receptors, respectively). It reduces agitation associated with schizophrenia or bipolar disorder. 8-OH Loxapine is considered inactive as it has relatively low affinity to dopamine and 5-HT receptors compared to the parent compound, however, 8-OH loxapine inhibits [14C]5-HT uptake in vitro (IC50 = 2 μM in human platelets).

Chemical properties

Pale Yellow Solid

The Uses of 8-hydroxyloxapine

The inactive

What are the applications of Application

8-Hydroxy Loxapine is an inactive metabolite of Loxapine

Properties of 8-hydroxyloxapine

Melting point: 212-215°C
storage temp.  Amber Vial, -20°C Freezer, Under Inert Atmosphere
solubility  DMSO: soluble
form  A solid
Stability: Light Sensitive

Safety information for 8-hydroxyloxapine

Computed Descriptors for 8-hydroxyloxapine

Related products of tetrahydrofuran

You may like

Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.