8-hydroxyloxapine
- CAS NO.：61443-77-4
- Empirical Formula: C18H18ClN3O2
- Molecular Weight: 343.81
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-20 11:41:24
What is 8-hydroxyloxapine?
Description
8-hydroxy Loxapine (8-OH loxapine) is a metabolite formed when loxapine , an atypical antipsychotic, is metabolized by the cytochrome P450 isoform CYP1A2. Loxapine displays high affinity for histamine, serotonin (5-HT), dopamine, and α1-adrenergic receptors (Ki values = 7, 7.7, 9.5, 12, and 31 nM for H1, 5-HT2A, 5-HT2C, D2, and α1A-adrenergic receptors, respectively). It reduces agitation associated with schizophrenia or bipolar disorder. 8-OH Loxapine is considered inactive as it has relatively low affinity to dopamine and 5-HT receptors compared to the parent compound, however, 8-OH loxapine inhibits [14C]5-HT uptake in vitro (IC50 = 2 μM in human platelets).
Chemical properties
Pale Yellow Solid
The Uses of 8-hydroxyloxapine
The inactive
What are the applications of Application
8-Hydroxy Loxapine is an inactive metabolite of Loxapine
Properties of 8-hydroxyloxapine
| Melting point: | 212-215°C |
| storage temp. | Amber Vial, -20°C Freezer, Under Inert Atmosphere |
| solubility | DMSO: soluble |
| form | A solid |
| Stability: | Light Sensitive |
Safety information for 8-hydroxyloxapine
Computed Descriptors for 8-hydroxyloxapine
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