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HomeProduct name list8-hydroxyloxapine

8-hydroxyloxapine

8-hydroxyloxapine Structural

What is 8-hydroxyloxapine?

Description

8-hydroxy Loxapine (8-OH loxapine) is a metabolite formed when loxapine , an atypical antipsychotic, is metabolized by the cytochrome P450 isoform CYP1A2. Loxapine displays high affinity for histamine, serotonin (5-HT), dopamine, and α1-adrenergic receptors (Ki values = 7, 7.7, 9.5, 12, and 31 nM for H1, 5-HT2A, 5-HT2C, D2, and α1A-adrenergic receptors, respectively). It reduces agitation associated with schizophrenia or bipolar disorder. 8-OH Loxapine is considered inactive as it has relatively low affinity to dopamine and 5-HT receptors compared to the parent compound, however, 8-OH loxapine inhibits [14C]5-HT uptake in vitro (IC50 = 2 μM in human platelets).

Chemical properties

Pale Yellow Solid

The Uses of 8-hydroxyloxapine

The inactive

What are the applications of Application

8-Hydroxy Loxapine is an inactive metabolite of Loxapine

Properties of 8-hydroxyloxapine

Melting point: 212-215°C
storage temp.  Amber Vial, -20°C Freezer, Under Inert Atmosphere
solubility  DMSO: soluble
form  A solid
Stability: Light Sensitive

Safety information for 8-hydroxyloxapine

Computed Descriptors for 8-hydroxyloxapine

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