7-Nitroindazole

Synonym(s):7-NI

CAS NO.：2942-42-9
Empirical Formula: C7H5N3O2
Molecular Weight: 163.13
MDL number: MFCD00022789
EINECS: 220-934-4
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-20 11:41:24

What is 7-Nitroindazole?

Description

7-Nitroindazole is a non-selective inhibitor of NOS isoforms in vitro. However, it shows good anti-nociceptive effects in vivo without affecting blood pressure via inhibition of eNOS. The IC₅₀ values for inhibition of rat nNOS, bovine eNOS, and rat iNOS are 0.71, 0.78, and 5.8 μM, respectively.

Chemical properties

yellow powder or Yellow orange solid soluble in DMSO.

The Uses of 7-Nitroindazole

7-nitroindazole is a specific inhibitor of neural nitric oxide synthase (nNOS), an enzyme that converts arginine to citrulline and nitric oxide (NO) in neuronal tissue. NO is a key player in the hippocampal long-term potentiation (LTP) and in general cell signaling.

What are the applications of Application

7-Nitroindazole is a specific inhibitor of neural nitric oxide synthase (nNOS)

Definition

7-Nitroindazole is a heterocyclic small molecule containing an indazole ring that has been nitrated at the 7 position. It is a potent, selective brain inhibitor of mouse cerebellar Nitric Oxide Synthase, a hemoprotein enzyme that, in neuronal tissue, converts arginine to citrulline and nitric oxide (NO).

Biological Activity

Sodium salt of the non-selective NOS inhibitor 7-nitroindazole (7-Nitroindazole).

Properties of 7-Nitroindazole

Melting point:	185-186°C
Boiling point:	290.19°C (rough estimate)
Density	1.4141 (rough estimate)
refractive index	1.5500 (estimate)
storage temp.	-20°C
solubility	Soluble to 100 mM in DMSO and to 20 mM in ethanol
form	powder to crystal
pka	10.03±0.40(Predicted)
color	Light yellow to Brown
Water Solubility	slightly soluble
BRN	6809
InChI	InChI=1S/C7H5N3O2/c11-10(12)6-3-1-2-5-4-8-9-7(5)6/h1-4H,(H,8,9)
CAS DataBase Reference	2942-42-9(CAS DataBase Reference)
NIST Chemistry Reference	7-Nitroindazole(2942-42-9)

Safety information for 7-Nitroindazole

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08
GHS Hazard Statements	H301:Acute toxicity,oral H319:Serious eye damage/eye irritation H351:Carcinogenicity H360:Reproductive toxicity
Precautionary Statement Codes	P201:Obtain special instructions before use. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.