7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL

Synonym(s):7-Chloro-4-hydroxyquinoline-2-carboxylic acid;7-Cl-KYNA

CAS NO.：18000-24-3
Empirical Formula: C10H6ClNO3
Molecular Weight: 223.61
MDL number: MFCD00069227
EINECS: 241-913-6
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-09 19:38:33

7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL Structural

What is 7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL?

The Uses of 7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL

NMDA receptor antagonist at the glycine site

What are the applications of Application

7-Chlorokynurenic acid is an NMDA receptor antagonist and inhibitor of EAAT

Definition

ChEBI: A quinolinemonocarboxylic acid that is quinaldic acid which is substituted by a hydroxy group at position 4 and by a chlorine at position 7. It is a potent NMDA glutamate receptor antagonist which antagonizes the strychnine-insensitive glycine site of the MDA receptor. It also prevents neurodegeneration produced by quinolinic acid.

Biological Functions

Glycine B agonist site antagonist of N-methyl-D-aspartate (NMDA) receptor (IC50=0.56 μM). 7-Chlorokynurenic acid is also a potent inhibitor of glutamate reuptake into synaptic vesicles with a Ki of 0.59 μM. 7-Chlorokynurenic acid has potent analgesic effects in neurotransmission.

Biological Activity

NMDA receptor antagonist acting at the glycine site. Potent competitive inhibitor of L-glutamate transport into synaptic vesicles. Also available as part of the NMDA Receptor - Glycine Site Tocriset™ .

in vivo

Male Sprague-Dawley rats pretreated with 7-Chlorokynurenic acid (10 nM) shows a significant retardation of development of both the electroencephalographic and motor (17.7±2.9 daily stimulations) components of the seizure response.

storage

Room temperature

Properties of 7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL

Melting point:	277-278 °C (decomp)
Boiling point:	461.5±45.0 °C(Predicted)
Density	1.600±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	0.1 M NaOH: 13.7 mg/mL
form	solid
pka	0.90±0.30(Predicted)
color	tan
CAS DataBase Reference	18000-24-3(CAS DataBase Reference)

Safety information for 7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.