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HomeProduct name list7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL

7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL

Synonym(s):7-Chloro-4-hydroxyquinoline-2-carboxylic acid;7-Cl-KYNA

  • CAS NO.:18000-24-3
  • Empirical Formula: C10H6ClNO3
  • Molecular Weight: 223.61
  • MDL number: MFCD00069227
  • EINECS: 241-913-6
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-17 08:48:38
7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL Structural

What is 7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL?

The Uses of 7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL

NMDA receptor antagonist at the glycine site

What are the applications of Application

7-Chlorokynurenic acid is an NMDA receptor antagonist and inhibitor of EAAT

Definition

ChEBI: A quinolinemonocarboxylic acid that is quinaldic acid which is substituted by a hydroxy group at position 4 and by a chlorine at position 7. It is a potent NMDA glutamate receptor antagonist which antagonizes the strychnine-insensitive glycine site of the MDA receptor. It also prevents neurodegeneration produced by quinolinic acid.

Biological Functions

Glycine B agonist site antagonist of N-methyl-D-aspartate (NMDA) receptor (IC50=0.56 μM). 7-Chlorokynurenic acid is also a potent inhibitor of glutamate reuptake into synaptic vesicles with a Ki of 0.59 μM. 7-Chlorokynurenic acid has potent analgesic effects in neurotransmission.

Biological Activity

NMDA receptor antagonist acting at the glycine site. Potent competitive inhibitor of L-glutamate transport into synaptic vesicles. Also available as part of the NMDA Receptor - Glycine Site Tocriset™ .

in vivo

Male Sprague-Dawley rats pretreated with 7-Chlorokynurenic acid (10 nM) shows a significant retardation of development of both the electroencephalographic and motor (17.7±2.9 daily stimulations) components of the seizure response.

storage

Room temperature

Properties of 7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL

Melting point: 277-278 °C (decomp)
Boiling point: 461.5±45.0 °C(Predicted)
Density  1.600±0.06 g/cm3(Predicted)
storage temp.  Sealed in dry,Room Temperature
solubility  0.1 M NaOH: 13.7 mg/mL
form  solid
pka 0.90±0.30(Predicted)
color  tan
CAS DataBase Reference 18000-24-3(CAS DataBase Reference)

Safety information for 7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL

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