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HomeProduct name list7-CHLORO-4-HYDROXY-QUINOLINE-3-CARBOXYLIC ACID METHYL ESTER

7-CHLORO-4-HYDROXY-QUINOLINE-3-CARBOXYLIC ACID METHYL ESTER

7-CHLORO-4-HYDROXY-QUINOLINE-3-CARBOXYLIC ACID METHYL ESTER Structural

What is 7-CHLORO-4-HYDROXY-QUINOLINE-3-CARBOXYLIC ACID METHYL ESTER?

Chemical properties

Crystalline compounds. Melting point 297 ℃.

The Uses of 7-CHLORO-4-HYDROXY-QUINOLINE-3-CARBOXYLIC ACID METHYL ESTER

Ethyl 7-chloro-4-hydroxyquinoline-3-carboxylate can be used as an intermediate of chloroquine.

Synthesis

Ethyl 7-chloro-4-hydroxyquinoline-3-carboxylate can be obtained by heating and condensing m-chloroaniline and triethyl orthoformate, then condensing with diethyl malonate with the participation of boron trifluoride, and finally heating and cyclizing in paraffin oil.

Properties of 7-CHLORO-4-HYDROXY-QUINOLINE-3-CARBOXYLIC ACID METHYL ESTER

Melting point: 296-298℃
Boiling point: 366.8±37.0 °C(Predicted)
Density  1.386
storage temp.  Sealed in dry,Room Temperature
pka 2.18±0.50(Predicted)

Safety information for 7-CHLORO-4-HYDROXY-QUINOLINE-3-CARBOXYLIC ACID METHYL ESTER

Signal word Warning
Pictogram(s)
ghs
Health Hazard
GHS08
GHS Hazard Statements H341:Germ cell mutagenicity
H361:Reproductive toxicity
Precautionary Statement Codes P201:Obtain special instructions before use.
P202:Do not handle until all safety precautions have been read and understood.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313:IF exposed or concerned: Get medical advice/attention.
P405:Store locked up.

Computed Descriptors for 7-CHLORO-4-HYDROXY-QUINOLINE-3-CARBOXYLIC ACID METHYL ESTER

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