7-CHLORO-4-HYDROXY-QUINOLINE-3-CARBOXYLIC ACID METHYL ESTER

CAS NO.：16600-22-9
Empirical Formula: C12H10ClNO3
Molecular Weight: 251.67
MDL number: MFCD00438741
SAFETY DATA SHEET (SDS)
Update Date: 2023-03-13 11:54:02

What is 7-CHLORO-4-HYDROXY-QUINOLINE-3-CARBOXYLIC ACID METHYL ESTER?

Chemical properties

Crystalline compounds. Melting point 297 ℃.

The Uses of 7-CHLORO-4-HYDROXY-QUINOLINE-3-CARBOXYLIC ACID METHYL ESTER

Ethyl 7-chloro-4-hydroxyquinoline-3-carboxylate can be used as an intermediate of chloroquine.

Synthesis

Ethyl 7-chloro-4-hydroxyquinoline-3-carboxylate can be obtained by heating and condensing m-chloroaniline and triethyl orthoformate, then condensing with diethyl malonate with the participation of boron trifluoride, and finally heating and cyclizing in paraffin oil.

Properties of 7-CHLORO-4-HYDROXY-QUINOLINE-3-CARBOXYLIC ACID METHYL ESTER

Melting point:	296-298℃
Boiling point:	366.8±37.0 °C(Predicted)
Density	1.386
storage temp.	Sealed in dry,Room Temperature
pka	2.18±0.50(Predicted)

Safety information for 7-CHLORO-4-HYDROXY-QUINOLINE-3-CARBOXYLIC ACID METHYL ESTER

Signal word	Warning
Pictogram(s)	Health Hazard GHS08
GHS Hazard Statements	H341:Germ cell mutagenicity H361:Reproductive toxicity
Precautionary Statement Codes	P201:Obtain special instructions before use. P202:Do not handle until all safety precautions have been read and understood. P280:Wear protective gloves/protective clothing/eye protection/face protection. P308+P313:IF exposed or concerned: Get medical advice/attention. P405:Store locked up.