6,6'-DITHIODINICOTINIC ACID
Synonym(s):Bis[3-carboxypyridine] 6,6′-disulfide
- CAS NO.：15658-35-2
- Empirical Formula: C12H8N2O4S2
- Molecular Weight: 308.33
- MDL number: MFCD00006454
- EINECS: 239-729-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-08 17:06:38
What is 6,6'-DITHIODINICOTINIC ACID?
Chemical properties
tan powder
The Uses of 6,6'-DITHIODINICOTINIC ACID
6,6′-Dithiodinicotinic acid may be employed as:
- specific thiol blocker to investigate the radioprotective effect of mercaptoethylamine on the thiol level of the outer cell membrane of the Ehrlich ascites tumor cells
- modifier to investigate the polar microenvironment around the reactive Cys283 of rabbit muscle creatine kinase
- dipyridyl-dithio substrate to evaluate the protein disulfide-thiol interchange activity of the auxin stimulated NADH: protein disulfide reductase (NADH oxidase) of soybean plasma membranes
- water-soluble reagent in a study for introducing, in buffered saline, a reactive sulfhydryl group on water-soluble molecules bearing an alkyl-amino group
- chromogen for sulfhydryl groups in the Ellman method for cholinesterase determinations
- spectrophotometric determination of thiols and of total glutathione in human blood
General Description
6,6′-Dithiodinicotinic acid is reported as sulphydryl reagent. 6,6′-Dithiodinicotinic acid is reported to react with thiols, to afford a disulfide and 6-mercaptonicotinic acid. Interaction of 6,6′-dithiodinicotinic acid with the homogenates of Ehrlich ascites cells has been reported.
Properties of 6,6'-DITHIODINICOTINIC ACID
| Melting point: | 263-265 °C(lit.) |
| Boiling point: | 584.2±50.0 °C(Predicted) |
| Density | 1.66±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| form | powder to crystal |
| pka | 2.82±0.10(Predicted) |
| color | White to Light yellow |
| Stability: | Stable. Incompatible with strong oxidizing agents. |
| CAS DataBase Reference | 15658-35-2(CAS DataBase Reference) |
Safety information for 6,6'-DITHIODINICOTINIC ACID
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 6,6'-DITHIODINICOTINIC ACID
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