6,6'-DITHIODINICOTINIC ACID

Synonym(s):Bis[3-carboxypyridine] 6,6′-disulfide

CAS NO.：15658-35-2
Empirical Formula: C12H8N2O4S2
Molecular Weight: 308.33
MDL number: MFCD00006454
EINECS: 239-729-6
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-19 20:33:22

What is 6,6'-DITHIODINICOTINIC ACID?

Chemical properties

tan powder

The Uses of 6,6'-DITHIODINICOTINIC ACID

6,6′-Dithiodinicotinic acid may be employed as:

specific thiol blocker to investigate the radioprotective effect of mercaptoethylamine on the thiol level of the outer cell membrane of the Ehrlich ascites tumor cells
modifier to investigate the polar microenvironment around the reactive Cys283 of rabbit muscle creatine kinase
dipyridyl-dithio substrate to evaluate the protein disulfide-thiol interchange activity of the auxin stimulated NADH: protein disulfide reductase (NADH oxidase) of soybean plasma membranes
water-soluble reagent in a study for introducing, in buffered saline, a reactive sulfhydryl group on water-soluble molecules bearing an alkyl-amino group
chromogen for sulfhydryl groups in the Ellman method for cholinesterase determinations
spectrophotometric determination of thiols and of total glutathione in human blood

General Description

6,6′-Dithiodinicotinic acid is reported as sulphydryl reagent. 6,6′-Dithiodinicotinic acid is reported to react with thiols, to afford a disulfide and 6-mercaptonicotinic acid. Interaction of 6,6′-dithiodinicotinic acid with the homogenates of Ehrlich ascites cells has been reported.

Properties of 6,6'-DITHIODINICOTINIC ACID

Melting point:	263-265 °C(lit.)
Boiling point:	584.2±50.0 °C(Predicted)
Density	1.66±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
form	powder to crystal
pka	2.82±0.10(Predicted)
color	White to Light yellow
Stability:	Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference	15658-35-2(CAS DataBase Reference)

Safety information for 6,6'-DITHIODINICOTINIC ACID

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.