6-O-Benzylguanine
- CAS NO.：19916-73-5
- Empirical Formula: C12H11N5O
- Molecular Weight: 241.25
- MDL number: MFCD00269931
- EINECS: 1592732-453-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-05-11 20:10:50
What is 6-O-Benzylguanine?
Chemical properties
Light Yellow Solid
The Uses of 6-O-Benzylguanine
An irreversible inhibitor of the mammalian DNA repair protein, O6-alkylguanine-DNA alkyltransferase. Assists in the protection against carcinogenic and therapeutic alkylating agents.
The Uses of 6-O-Benzylguanine
O6-Benzylguanine is an effective substrate and efficient inactivator of DNA alkyltransferase. O6-Benzylguanine is an inhibitor of MGMT. It is also used as an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff.
What are the applications of Application
O6-Benzylguanine is an effective substrate and efficient inactivator of DNA alkyltransferase
Biochem/physiol Actions
O6-Benzylguanine (O6BG) inhibits methylguanine methyltransferase (MGMT) by blocking the active site through benzyl group transfer. The use of O6BG with bis-chloroethylnitrosourea (BCNU) or carmustine is effective in treating solid tumors including lymphomas, melanomas and sarcoma.
Properties of 6-O-Benzylguanine
| Melting point: | 193(dec.) |
| Boiling point: | 459.3±55.0 °C(Predicted) |
| Density | 1.48±0.1 g/cm3(Predicted) |
| storage temp. | room temp |
| solubility | methanol: 20 mg/mL |
| form | solid |
| pka | 7.47±0.20(Predicted) |
| color | Off-White to Light Yellow |
| CAS DataBase Reference | 19916-73-5(CAS DataBase Reference) |
Safety information for 6-O-Benzylguanine
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 6-O-Benzylguanine
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