6-Nitroindoline

Synonym(s):6-Nitro-2,3-dihydroindole;NSC 80658

CAS NO.：19727-83-4
Empirical Formula: C8H8N2O2
Molecular Weight: 164.16
MDL number: MFCD00005710
EINECS: 243-257-6
SAFETY DATA SHEET (SDS)
Update Date: 2023-04-23 13:52:06

What is 6-Nitroindoline?

Chemical properties

orange crystalline powder or red crystals

The Uses of 6-Nitroindoline

• ;Reactant for preparation of 2-[(2,3-Dihydro-1H-indol-1-yl)methyl]melatonin analogs as novel MT2-selective melatonin receptor antagonists1• ;Reactant for synthesis of isoindigo and azaisoindigo glycosides as anticancer agents2• ;Reactant for preparation of arylfurancarboxamides with Nav1.8 voltage-gated Na channel blocking/analgesic activities3• ;Reactant for preparation of bicyclic benzamides as 5-HT1 receptor agonists4• ;Reactant for preparation of antiarrhythmic benzopyrans5• ;Reactant for preparation of 5-HT2C/2B receptor antagonists6

The Uses of 6-Nitroindoline

Reactant for preparation of 2-[(2,3-Dihydro-1H-indol-1-yl)methyl]melatonin analogs as novel MT2-selective melatonin receptor antagonists
Reactant for synthesis of isoindigo and azaisoindigo glycosides as anticancer agents
Reactant for preparation of arylfurancarboxamides with Nav1.8 voltage-gated Na channel blocking/analgesic activities
Reactant for preparation of bicyclic benzamides as 5-HT1 receptor agonists
Reactant for preparation of antiarrhythmic benzopyrans
Reactant for preparation of 5-HT2C/2B receptor antagonists

Properties of 6-Nitroindoline

Melting point:	67-69 °C (lit.)
Boiling point:	291.62°C (rough estimate)
Density	1.2739 (rough estimate)
refractive index	1.6000 (estimate)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
pka	3.39±0.20(Predicted)
form	Crystalline Powder or Crystals
color	Orange or red
BRN	156434
CAS DataBase Reference	19727-83-4(CAS DataBase Reference)

Safety information for 6-Nitroindoline

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.