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HomeProduct name list6-Nitroindoline

6-Nitroindoline

Synonym(s):6-Nitro-2,3-dihydroindole;NSC 80658

  • CAS NO.:19727-83-4
  • Empirical Formula: C8H8N2O2
  • Molecular Weight: 164.16
  • MDL number: MFCD00005710
  • EINECS: 243-257-6
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-04-23 13:52:06
6-Nitroindoline Structural

What is 6-Nitroindoline?

Chemical properties

orange crystalline powder or red crystals

The Uses of 6-Nitroindoline

• ;Reactant for preparation of 2-[(2,3-Dihydro-1H-indol-1-yl)methyl]melatonin analogs as novel MT2-selective melatonin receptor antagonists1• ;Reactant for synthesis of isoindigo and azaisoindigo glycosides as anticancer agents2• ;Reactant for preparation of arylfurancarboxamides with Nav1.8 voltage-gated Na channel blocking/analgesic activities3• ;Reactant for preparation of bicyclic benzamides as 5-HT1 receptor agonists4• ;Reactant for preparation of antiarrhythmic benzopyrans5• ;Reactant for preparation of 5-HT2C/2B receptor antagonists6

The Uses of 6-Nitroindoline

  • Reactant for preparation of 2-[(2,3-Dihydro-1H-indol-1-yl)methyl]melatonin analogs as novel MT2-selective melatonin receptor antagonists
  • Reactant for synthesis of isoindigo and azaisoindigo glycosides as anticancer agents
  • Reactant for preparation of arylfurancarboxamides with Nav1.8 voltage-gated Na channel blocking/analgesic activities
  • Reactant for preparation of bicyclic benzamides as 5-HT1 receptor agonists
  • Reactant for preparation of antiarrhythmic benzopyrans
  • Reactant for preparation of 5-HT2C/2B receptor antagonists

Properties of 6-Nitroindoline

Melting point: 67-69 °C (lit.)
Boiling point: 291.62°C (rough estimate)
Density  1.2739 (rough estimate)
refractive index  1.6000 (estimate)
storage temp.  under inert gas (nitrogen or Argon) at 2–8 °C
pka 3.39±0.20(Predicted)
form  Crystalline Powder or Crystals
color  Orange or red
BRN  156434
CAS DataBase Reference 19727-83-4(CAS DataBase Reference)

Safety information for 6-Nitroindoline

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 6-Nitroindoline

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