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HomeProduct name list6-Methylisoquinoline

6-Methylisoquinoline

  • CAS NO.:42398-73-2
  • Empirical Formula: C10H9N
  • Molecular Weight: 143.19
  • MDL number: MFCD09258767
  • EINECS: 255-794-3
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-05-09 09:30:45
6-Methylisoquinoline Structural

What is 6-Methylisoquinoline?

Chemical properties

Light beige powder

The Uses of 6-Methylisoquinoline

6-Methylisoquinoline (cas# 42398-73-2) is a useful reagent for the green preparation of polyfluoroarylated heterocyclic compounds.

Preparation

A benzene solution (50 ml, CAUTION) of equimolar amounts of p-tolualdehyde (8.4 g, 0.07 mol) and aminoacetaldehyde dimethyl acetal (7.35 g, 0.07 mol) is refluxed overnight into a Dean and Stark trap. The solution is evaporated in vacuo and then twice evaporated again with added benzene and the viscous oil dissolved in dry tetrahydrofuran. This solution is cooled to - 10 °C and 1 equivalent of ethyl chloroformate (7. 1 ml, 0.07 mol) is added with rapid stirring and the mixture stirred for a further 5 minutes. The cooling bath is removed and 1.2 equivalents of trimethyl phosphite ( 10.5 ml, 0.09 mol) is added with stirring. The solution is stirred at room temperature for 1 5 hours and then evaporated t o an oil. The oil is then re-evaporated twice with added toluene to remove traces of trimethyl phosphite. The oil is dissolved in dry dichloromethane, 6 equivalents of titanium(1v) chloride (50 ml, 0.45 mol) is added and the solution refluxed for 36 hours under a drying tube. The cooled solution is shaken with 1 equivalent of aqueous sodium hydroxide solution to neutrality, whereupon titanium(1v) oxide precipitates as a white solid. The filtered organic layer is extracted with 3 M hydrochloric acid, and the extract is washed with dichloromethane, basified strongly with aqueous alkali, and extracted with dichloromethane. This organic extract is dried over anhydrous sodium sulphate and evaporated to afford 6-methylisoquinoline (yield 7 1 %, m.p. 88 °C).

Synthesis Reference(s)

The Journal of Organic Chemistry, 48, p. 3344, 1983 DOI: 10.1021/jo00167a043

Properties of 6-Methylisoquinoline

Melting point: 85.5°C
Boiling point: 246.29°C (estimate)
Density  1.0584 (estimate)
refractive index  1.6103 (estimate)
pka 5.85±0.10(Predicted)
color  Beige
CAS DataBase Reference 42398-73-2(CAS DataBase Reference)

Safety information for 6-Methylisoquinoline

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 6-Methylisoquinoline

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