6-Methoxyquinoline

Synonym(s):6-Methoxyquinoline

colorless to light yellow liquid

6-Methoxyquinoline is a useful sythetic intermediate

6-Methoxyquinoline is used as a precursor in the synthesis of:

Fluorescent zinc and chlorine sensors.
5-Amino-2-aroylquinolines as potent tubulin polymerization inhibitors.
3-Fluoro-6-methoxyquinoline derivatives as inhibitors of bacterial DNA gyrase and topoisomerase.
Cobalt-based ternary metal-organic complex as single?ion magnets.

6-Methoxyquinoline is A useful sythetic intermediate

ChEBI: An aromatic ether that is quinoline substituted at position 6 by a methoxy group.

Journal of the American Chemical Society, 68, p. 1584, 1946 DOI: 10.1021/ja01212a062

Melting point:	18-20 °C (lit.)
Boiling point:	140-146 °C/15 mmHg (lit.)
Density	1.15 g/mL at 20 °C (lit.)
refractive index	n20/D 1.625(lit.)
FEMA	4640 \| 6-METHOXYQUINOLINE
Flash point:	>230 °F
storage temp.	Store below +30°C.
solubility	soluble in Alcohol
pka	5.03(at 20℃)
form	Granular Powder
color	White to cream
Odor	heavy sweet
Water Solubility	insoluble
Sensitive	Light Sensitive
JECFA Number	2157
BRN	115244
CAS DataBase Reference	5263-87-6(CAS DataBase Reference)
NIST Chemistry Reference	Quinoline, 6-methoxy-(5263-87-6)
EPA Substance Registry System	Quinoline, 6-methoxy- (5263-87-6)

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention.