6-METHOXY-2-NAPHTHYLACETIC ACID
Synonym(s):6-Methoxy-2-naphthaleneacetic acid;6-Methoxy-2-naphthylacetic acid;Naproxen impurity I
- CAS NO.:23981-47-7
- Empirical Formula: C13H12O3
- Molecular Weight: 216.23
- MDL number: MFCD00033105
- EINECS: 245-967-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-07-26 13:24:24
What is 6-METHOXY-2-NAPHTHYLACETIC ACID?
Chemical properties
Yellow Solid
The Uses of 6-METHOXY-2-NAPHTHYLACETIC ACID
A metabolite of Nabumetone. A competitive, non-selective COX inhibitor
The Uses of 6-METHOXY-2-NAPHTHYLACETIC ACID
A metabolite of Nabumetone. A competitive, non-selective COX inhibitor.
What are the applications of Application
6-Methoxy-2-Naphthylacetic acid is a competitive and selective inhibitor of Cox-2
Definition
ChEBI: (6-methoxy-2-naphthyl)acetic acid is a monocarboxylic acid consisting of 2-naphthylacetic acid having a methoxy substituent at the 6-position. The active metabolite of the prodrug nabumetone. It has a role as an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor, a drug metabolite and a xenobiotic metabolite. It is a monocarboxylic acid and a methoxynaphthalene. It is functionally related to a 2-naphthylacetic acid.
Biological Activity
6-methoxy naphthalene acetic acid is a competitive and non-selective cox inhibitor with ki values of 21 and 19 μm for ovine cox-1 and -2, respectively [1][2][3].cyclooxygenase (cox), also known as prostaglandin-endoperoxide synthase (ptgs, pghs), is an enzyme responsible for formation of prostanoids, including thromboxane and prostaglandins such as prostacyclin. cox-1 is the constitutive isoform and is mainly responsible for the synthesis of cytoprotective prostaglandins in the gastrointestinal tract (gi) and of the proaggregatory thromboxane in blood platelets. cox-2 is inducible and short-lived that is stimulated by endotoxin, cytokines, and mitogens. cox-2 plays important roles in prostaglandin biosynthesis in inflammatory cells the central nervous system [1][2].6-methoxy naphthalene acetic acid (6-mna) is a competitive and non-selective cox inhibitor with ki values of 21 and 19 μm for ovine cox-1 and -2, respectively [1][2]. 6-mna is a metabolite of nebumetome. 6-mna inhibited human recombinant cox-1 and -2 with ic50 values of 70 and 20 μm, respectively [1].
References
[1]. barnett j, chow j, ives d, et al. purification, characterization and selective inhibition of human prostaglandin g/h synthase 1 and 2 expressed in the baculovirus system. biochim biophys acta. 1994 nov 16;1209(1):130-9.
[2]. johnson jl, wimsatt j, buckel sd, et al. purification and characterization of prostaglandin h synthase-2 from sheep placental cotyledons. arch biochem biophys. 1995 dec 1;324(1):26-34.
[3]. laneuville o1, breuer dk, dewitt dl, et al. differential inhibition of human prostaglandin endoperoxide h synthases-1 and -2 by nonsteroidal anti-inflammatory drugs. j pharmacol exp ther. 1994 nov;271(2):927-34.
Properties of 6-METHOXY-2-NAPHTHYLACETIC ACID
Melting point: | 170-172°C |
Boiling point: | 408.8±20.0 °C(Predicted) |
Density | 1.235 |
RTECS | QJ1045000 |
storage temp. | Sealed in dry,2-8°C |
solubility | DMSO (Slightly), Methanol (Slightly) |
pka | 4.35±0.30(Predicted) |
form | Off-white solid. |
color | Off-White to Yellow |
Safety information for 6-METHOXY-2-NAPHTHYLACETIC ACID
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 6-METHOXY-2-NAPHTHYLACETIC ACID
Abamectin manufacturer
SYNTHINK RESEARCH CHEMICALS
New Products
Tubulysin D Tubulysin F Tubulysin G 3-METHYLAZETIDIN-3-OL HYDROCHLORIDE 1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE 2-(azetidin-3-ylidene)acetonitrile (hydrochloride) 2H-Pyran, 4-ethynyltetrahydro- 4,4-DIFLUOROCYCLOHEXANAMINE 2,2-Difluoropropylamine hydrochloride 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol Calcium Sodium Phosphosilicate IH 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Imeglimin Hydrochloride IH Latanoprostene Bunod Lubiprostone Magnesium Trisilicate Flame Retardant Zinc Borate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate methyl 3-fluoro-4- thiomorpholino phenylcarbamate 7-Methoxyquinoline-4-carboxylic acid 1H-Imidazole-4-carbonitrile 7-Methoxyquinoline-4-carbonitrileRelated products of tetrahydrofuran
You may like
-
23981-47-7 Naproxen EP Impurity I 98%View Details
23981-47-7 -
2-(6-Methoxynaphthalen-2-yl)acetic acid CAS 23981-47-7View Details
23981-47-7 -
(R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonateView Details
2416850-45-6 -
methyl 3-fluoro-4- thiomorpholino phenylcarbamateView Details
2760359-22-4 -
4,6-dichloro-2-propylthiopyrimidine-5-amine 145783-15-9 98%View Details
145783-15-9 -
151767-02-1 Montelukast Sodium IP/USP 98%View Details
151767-02-1 -
Valacyclovir Hydrochloride IH 98%View Details
124832-27-5 -
2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 98%View Details
142569-70-8