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HomeProduct name list6-HYDROXYDOPAMINE HYDROBROMIDE

6-HYDROXYDOPAMINE HYDROBROMIDE

Synonym(s):2-(2,4,5-Trihydroxyphenyl)ethylamine hydrobromide;2,4,5-Trihydroxyphenethylamine hydrobromide;2,5-Dihydroxytyramine hydrobromide;6-OHDA

  • CAS NO.:636-00-0
  • Empirical Formula: C8H12BrNO3
  • Molecular Weight: 250.09
  • MDL number: MFCD00012894
  • EINECS: 211-247-0
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 23:02:33
6-HYDROXYDOPAMINE HYDROBROMIDE Structural

What is 6-HYDROXYDOPAMINE HYDROBROMIDE?

Description

6-OHDA is a catecholaminergic neurotoxin that has been used to induce dopaminergic lesions and parkinsonian symptoms as a model of Parkinson''s disease in rodents. It induces locomotor impairment in mice and loss of tyrosine hydroxylase-reactive neurons in mouse brain when administered into the substantia nigra, medial forebrain bundle (MFB), or striatum at doses of 9, 6, and 18 μg, respectively. Intracisternal administration of 6-OHDA (200 μg) decreases dopamine and norepinephrine levels in rat brain. It induces apoptosis in primary rat cortical cells and PC12 rat adrenal cells when used at a concentration of 50 μM. 6-OHDA (75 μM) activates caspase-3, -8, and -9 in a time-dependent manner and increases the level of intracellular reactive oxygen species (ROS) in PC12 cells and induces apoptosis in rat substantia nigra when stereotaxically injected into the right MFB.

Chemical properties

beige to brown crystalline powder

The Uses of 6-HYDROXYDOPAMINE HYDROBROMIDE

6-Hydroxydopamine is a selective catecholaminergic neurotoxin. Studies show that 6-Hydroxydopamine can be used to create an animal model of Parkinson''s disease as it causes almost complete destruction of nigral dopaminergic neurons and their striatal terminals when injected into the substantia nigra of rats. 6-Hydroxydopamine induces apoptosis in PC12 cells.

What are the applications of Application

6-Hydroxydopamine hydrobromide is an oxygen compound that destroys catecholaminergic terminals

General Description

Solutions should be freshly prepared and protected from exposure to light.

Biochem/physiol Actions

Neurotoxin that destroys catecholaminergic terminals.

storage

-20°C

Properties of 6-HYDROXYDOPAMINE HYDROBROMIDE

Melting point: 216-220 °C(lit.)
storage temp.  -20°C
solubility  DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form  solid
color  tan to brown
BRN  3713280
Stability: Hygroscopic, Light Sensitive
CAS DataBase Reference 636-00-0(CAS DataBase Reference)

Safety information for 6-HYDROXYDOPAMINE HYDROBROMIDE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 6-HYDROXYDOPAMINE HYDROBROMIDE

InChIKey MLACDGUOKDOLGC-UHFFFAOYSA-N

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