6-Hydroxy-2-naphthoic acid

CAS NO.：16712-64-4
Empirical Formula: C11H8O3
Molecular Weight: 188.18
MDL number: MFCD00060070
EINECS: 240-759-7
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-04 13:44:46

What is 6-Hydroxy-2-naphthoic acid?

Chemical properties

pale brown powder

The Uses of 6-Hydroxy-2-naphthoic acid

6-hydroxy-2-naphthoic acid is used for preparation engineering plastics, organic pigments, liquid crystal materials, medicine, particularly as a monomer of heat-resistant material.

The Uses of 6-Hydroxy-2-naphthoic acid

6-Hydroxy-2-naphthoic acid may be used in the synthesis of 5-bromo-6-hydroxy-2-naphthoic acid and liquid-crystalline epoxy resins.

Definition

ChEBI: 6-Hydroxy-2-naphthoic acid is a naphthoic acid.

General Description

6-Hydroxy-2-naphthoic acid is a hydroxynaphthoic acid derivative. Whole cells of the recombinant Escherichia coli strain expressing CYP199A2 were reported to catalyze the regioselective oxidation of 6-hydroxy-2-naphthoic acid to afford 6,7-dihydroxynaphthoic acid. It can form co-crystals with caffeine.

Flammability and Explosibility

Non flammable

Synthesis

6-Hydroxy-2-naphthoic acid [16712-64-4], mp 245 – 248℃, is synthesized by carboxylation of the potassium salt of 2-naphthol at 170 – 230℃. It couples with diazo compounds in the 5-position and undergoes sulfonation in the 4- and 7-positions.

Properties of 6-Hydroxy-2-naphthoic acid

Melting point:	240-250 °C (lit.)
Boiling point:	283.17°C (rough estimate)
Density	1.2100 (rough estimate)
vapor pressure	0Pa at 25℃
refractive index	1.6400 (estimate)
storage temp.	Sealed in dry,Room Temperature
solubility	Insoluble in water
pka	4.34±0.30(Predicted)
form	Powder
color	Pale brown
Water Solubility	99mg/L at 20℃
BRN	2692084
CAS DataBase Reference	16712-64-4(CAS DataBase Reference)
EPA Substance Registry System	6-Hydroxy-2-naphthoic acid (16712-64-4)

Safety information for 6-Hydroxy-2-naphthoic acid

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H303:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.